GUCY1A2

From Wikipedia, the free encyclopedia

Guanylate cyclase 1, soluble, alpha 2

Identifiers

GUCY1A2; GC-SA2; GUC1A2

External IDs

OMIM: 601244 MGI: 2660877 HomoloGene: 47953

Gene ontology
Molecular Function:	• guanylate cyclase activity • heme binding
Cellular Component:	• cytoplasm • guanylate cyclase complex, soluble
Biological Process:	• cGMP biosynthetic process • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_000855 (mRNA)
NP_000846 (protein)

XM_001002873 (mRNA)
XP_001002873 (protein)

Location

Chr 11: 106.06 - 106.39 Mb

Chr 9: 3.53 - 3.89 Mb

Pubmed search

[1]

[2]

Guanylate cyclase 1, soluble, alpha 2, also known as GUCY1A2, is a human gene.^[1]

[edit] References

^ Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2.

[edit] Further reading

Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain.". Neuroreport 15 (4): 677-80. PMID 15094474.
Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507-10. doi:10.1073/pnas.012368499. PMID 11752394.
Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.". J. Biol. Chem. 276 (48): 44647-52. doi:10.1074/jbc.M105587200. PMID 11572861.
Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit.". J. Clin. Endocrinol. Metab. 86 (2): 909-12. PMID 11158065.
Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases.". Biochem. Biophys. Res. Commun. 263 (3): 696-701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11.". Genomics 33 (2): 334-6. doi:10.1006/geno.1996.0208. PMID 8660992.
Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein.". J. Biol. Chem. 270 (36): 21109-13. PMID 7673142.
Harteneck C, Wedel B, Koesling D, et al. (1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.". FEBS Lett. 292 (1-2): 217-22. PMID 1683630.