Guanosine nucleotide dissociation inhibitors

From Wikipedia, the free encyclopedia

The Guanosine nucleotide dissociation inhibitors (GDIs), bind to the GDP-bound form of Rho and Rab small GTPases and not only prevent exchange (maintaining the small GTPase in an off-state), but also prevent the small GTPase from localizing at the membrane, which is their place of action.

[edit] External links

• MeSH Guanine+Nucleotide+Dissociation+Inhibitors

v • d • e GTP-binding protein regulators GTPase activating protein Chimerin 1 - RasGAP (Neurofibromin 1, IQ motif containing GTPase activating protein) Guanine nucleotide exchange factor EIF-2 - Son of Sevenless - Ras-GRF1 Other Guanosine nucleotide dissociation inhibitors