Guanosine-5'-triphosphate,3'-diphosphate diphosphatase

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In enzymology, a guanosine-5'-triphosphate,3'-diphosphate diphosphatase (EC 3.6.1.40) is an enzyme that catalyzes the chemical reaction

guanosine 5'-triphosphate,3'-diphosphate + H2O \rightleftharpoons guanosine 5'-diphosphate,3'-diphosphate + phosphate

Thus, the two substrates of this enzyme are guanosine 5'-triphosphate,3'-diphosphate and H2O, whereas its two products are guanosine 5'-diphosphate,3'-diphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase. Other names in common use include pppGpp 5'-phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase, and guanosine pentaphosphate phosphohydrolase. This enzyme participates in purine metabolism.

Contents

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6C and 1T6D.

[edit] References

[edit] External links

The CAS registry number for this enzyme class is 85130-44-5.

[edit] Gene Ontology (GO) codes

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