Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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In enzymology, a guanosine-3',5'-bis(diphosphate) 3'-diphosphatase (EC 3.1.7.2) is an enzyme that catalyzes the chemical reaction

guanosine 3',5'-bis(diphosphate) + H₂O $\rightleftharpoons$ guanosine 5'-diphosphate + diphosphate

Thus, the two substrates of this enzyme are guanosine 3',5'-bis(diphosphate) and H₂O, whereas its two products are guanosine 5'-diphosphate and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on diphosphoric monoester bonds. The systematic name of this enzyme class is guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase. Other names in common use include guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, PpGpp-3'-pyrophosphohydrolase, and PpGpp phosphohydrolase. This enzyme participates in purine metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VJ7.

[edit] References

IUBMB entry for 3.1.7.2
BRENDA references for 3.1.7.2 (Recommended.)
PubMed references for 3.1.7.2
PubMed Central references for 3.1.7.2
Google Scholar references for 3.1.7.2
Heinemeyer EA, Richter D (1978). "Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli". Biochemistry. 17: 5368–72. PMID 365225.
Richter D, Fehr S, Harder R (1979). "The guanosine 3',5'-bis(diphosphate) (ppGpp) cycle. Comparison of synthesis and degradation of guanosine 3',5'-bis(diphosphate) in various bacterial systems". Eur. J. Biochem. 99: 57–64. PMID 114395.