Guanidinobutyrase

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In enzymology, a guanidinobutyrase (EC 3.5.3.7) is an enzyme that catalyzes the chemical reaction

4-guanidinobutanoate + H₂O $\rightleftharpoons$ 4-aminobutanoate + urea

Thus, the two substrates of this enzyme are 4-guanidinobutanoate and H₂O, whereas its two products are 4-aminobutanoate and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is 4-guanidinobutanoate amidinohydrolase. Other names in common use include gamma-guanidobutyrase, 4-guanidinobutyrate amidinobutyrase, gamma-guanidinobutyrate amidinohydrolase, G-Base, GBH, and guanidinobutyrate ureahydrolase. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, manganese.

[edit] References

IUBMB entry for 3.5.3.7
BRENDA references for 3.5.3.7 (Recommended.)
PubMed references for 3.5.3.7
PubMed Central references for 3.5.3.7
Google Scholar references for 3.5.3.7
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K (1983). "Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping". Agric. Biol. Chem. 47: 2825–2830.