Guanidinoacetase

From Wikipedia, the free encyclopedia

In enzymology, a guanidinoacetase (EC 3.5.3.2) is an enzyme that catalyzes the chemical reaction

guanidinoacetate + H₂O glycine + urea

Thus, the two substrates of this enzyme are guanidinoacetate and H₂O, whereas its two products are glycine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is guanidinoacetate amidinohydrolase. This enzyme is also called glycocyaminase. It employs one cofactor, manganese.

[edit] References

• IUBMB entry for 3.5.3.2
• BRENDA references for 3.5.3.2 (Recommended.)
• PubMed references for 3.5.3.2
• PubMed Central references for 3.5.3.2
• Google Scholar references for 3.5.3.2
• ROCHE J, LACOMBE G, GIRARD H (1950). "[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]". Biochim. Biophys. Acta. 6: 210–6. PMID 14791411. 
• Yorifuji T, Tamai H and Usami H (1977). "Purification, crystallization and properties of Mn2+ dependent guanidoacetate amidinohydrolase from a Pseudomonas". Agric. Biol. Chem. 41: 959–966. 

[edit] External links

The CAS registry number for this enzyme class is 9024-92-4.

• IUBMB entry for 3.5.3.2

• KEGG entry for 3.5.3.2

• BRENDA entry for 3.5.3.2

• NiceZyme view of 3.5.3.2

• EC2PDB: PDB structures for 3.5.3.2

• PRIAM entry for 3.5.3.2

• PUMA2 entry for 3.5.3.2

• IntEnz: Integrated Enzyme entry for 3.5.3.2

• MetaCyc entry for 3.5.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047970: guanidinoacetase

• AMIGO entry for GO code 0047970: guanidinoacetase