Guanabenz

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Guanabenz
Systematic (IUPAC) name
(2,6-dichlorophenyl)methylideneaminoiminomethanediamine
Identifiers
CAS number	5051-62-7
ATC code	?
PubChem	3517
DrugBank	APRD00487
Chemical data
Formula	C8H8Cl2N4
Mol. mass	231.081 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	?
Half life	6 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status
Routes	?

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 type that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension).

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

v • d • e Antihypertensives (C02) and diuretics (C03) Sympatholytic agents (including alpha) centrally acting/antiadrenergics: Clonidine • Guanfacine • Methyldopa • Moxonidine • Rilmenidine • adrenergic uptake inhibitor (Rescinnamine, Reserpine) ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin) Vasodilators Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine Other antihypertensives serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) Low ceiling diuretics Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine High ceiling diuretics Loop diuretic (Bumetanide, Furosemide, Torasemide) Potassium-sparing diuretics ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)