GTP cyclohydrolase IIa

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In enzymology, a GTP cyclohydrolase IIa (EC 3.5.4.29) is an enzyme that catalyzes the chemical reaction

GTP + 3 H₂O 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate

Thus, the two substrates of this enzyme are GTP and H₂O, whereas its two products are 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one and phosphate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 8,9-hydrolase (phosphate-forming).

[edit] References

• IUBMB entry for 3.5.4.29
• BRENDA references for 3.5.4.29 (Recommended.)
• PubMed references for 3.5.4.29
• PubMed Central references for 3.5.4.29
• Google Scholar references for 3.5.4.29
• Graham DE, Xu H, White RH (2002). "A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates". Biochemistry. 41: 15074–84. doi:10.1021/bi0268798. PMID 12475257. 

[edit] External links

• IUBMB entry for 3.5.4.29

• KEGG entry for 3.5.4.29

• BRENDA entry for 3.5.4.29

• NiceZyme view of 3.5.4.29

• EC2PDB: PDB structures for 3.5.4.29

• PRIAM entry for 3.5.4.29

• PUMA2 entry for 3.5.4.29

• IntEnz: Integrated Enzyme entry for 3.5.4.29

• MetaCyc entry for 3.5.4.29

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043740: GTP cyclohydrolase IIa

• AMIGO entry for GO code 0043740: GTP cyclohydrolase IIa