GTP cyclohydrolase II

From Wikipedia, the free encyclopedia

In enzymology, a GTP cyclohydrolase II (EC 3.5.4.25) is an enzyme that catalyzes the chemical reaction

GTP + 3 H₂O formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate

Thus, the two substrates of this enzyme are GTP and H₂O, whereas its 3 products are formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine, and diphosphate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is GTP 7,8-8,9-dihydrolase (diphosphate-forming). Other names in common use include guanosine triphosphate cyclohydrolase II, and GTP-8-formylhydrolase. This enzyme participates in riboflavin metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2BZ0 and 2BZ1.

[edit] References

• IUBMB entry for 3.5.4.25
• BRENDA references for 3.5.4.25 (Recommended.)
• PubMed references for 3.5.4.25
• PubMed Central references for 3.5.4.25
• Google Scholar references for 3.5.4.25
• Foor F, Brown GM (1975). "Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli". J. Biol. Chem. 250: 3545–51. PMID 235552. 

[edit] External links

The CAS registry number for this enzyme class is 56214-35-8.

• IUBMB entry for 3.5.4.25

• KEGG entry for 3.5.4.25

• BRENDA entry for 3.5.4.25

• NiceZyme view of 3.5.4.25

• EC2PDB: PDB structures for 3.5.4.25

• PRIAM entry for 3.5.4.25

• PUMA2 entry for 3.5.4.25

• IntEnz: Integrated Enzyme entry for 3.5.4.25

• MetaCyc entry for 3.5.4.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003935: GTP cyclohydrolase II

• AMIGO entry for GO code 0003935: GTP cyclohydrolase II