GTPBP1

From Wikipedia, the free encyclopedia

GTP binding protein 1

Identifiers

GTPBP1; GP-1; GP1; HSPC018; MGC20069

External IDs

OMIM: 602245 MGI: 109443 HomoloGene: 3165

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding • electron carrier activity • protein disulfide oxidoreductase activity
Biological Process:	• immune response • signal transduction • cell redox homeostasis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004286 (mRNA)
NP_004277 (protein)

NM_013818 (mRNA)
NP_038846 (protein)

Location

Chr 22: 37.43 - 37.46 Mb

Chr 15: 79.52 - 79.55 Mb

Pubmed search

[1]

[2]

GTP binding protein 1, also known as GTPBP1, is a human gene.^[1]

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype.^[1]

[edit] References

^ ^a ^b Entrez Gene: GTPBP1 GTP binding protein 1.

[edit] Further reading

Senju S, Nishimura Y (1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family.". Biochem. Biophys. Res. Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein.". Biochem. J. 336 ( Pt 2): 381–6. PMID 9820815.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1.". Mol. Cell. Biol. 20 (17): 6195–200. PMID 10938096.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.