GTF2F2

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General transcription factor IIF, polypeptide 2, 30kDa
PDB rendering based on 1bby.
Available structures: 1bby, 1f3u, 2bby
Identifiers
Symbol(s) GTF2F2; BTF4; TFIIF; RAP30; TF2F2
External IDs OMIM: 189969 MGI: 1915955 HomoloGene: 37884
Orthologs
Human Mouse
Entrez 2963 68705
Ensembl ENSG00000188342 ENSMUSG00000067995
Uniprot P13984 Q3UMJ4
Refseq NM_004128 (mRNA)
NP_004119 (protein)		 NM_026816 (mRNA)
NP_081092 (protein)
Location Chr 13: 44.59 - 44.76 Mb Chr 14: 74.63 - 74.75 Mb
Pubmed search [1] [2]

General transcription factor IIF, polypeptide 2, 30kDa, also known as GTF2F2, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa.

[edit] Further reading

  • Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.". Genes Dev. 6 (4): 655-66. PMID 1559613. 
  • Horikoshi M, Fujita H, Wang J, et al. (1991). "Nucleotide and amino acid sequence of RAP30.". Nucleic Acids Res. 19 (19): 5436. PMID 1840667. 
  • Sopta M, Burton ZF, Greenblatt J (1989). "Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.". Nature 341 (6241): 410-4. doi:10.1038/341410a0. PMID 2477704. 
  • Sopta M, Carthew RW, Greenblatt J (1985). "Isolation of three proteins that bind to mammalian RNA polymerase II.". J. Biol. Chem. 260 (18): 10353-60. PMID 3860504. 
  • Tan S, Aso T, Conaway RC, Conaway JW (1994). "Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase II.". J. Biol. Chem. 269 (41): 25684-91. PMID 7929273. 
  • Heng HH, Xiao H, Shi XM, et al. (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome.". Hum. Mol. Genet. 3 (1): 61-4. PMID 8162052. 
  • Yonaha M, Aso T, Kobayashi Y, et al. (1993). "Domain structure of a human general transcription initiation factor, TFIIF.". Nucleic Acids Res. 21 (2): 273-9. PMID 8441635. 
  • Tang H, Sun X, Reinberg D, Ebright RH (1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1119-24. PMID 8577725. 
  • Martin ML, Lieberman PM, Curran T (1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.". Mol. Cell. Biol. 16 (5): 2110-8. PMID 8628277. 
  • Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.". J. Biol. Chem. 271 (20): 11703-9. PMID 8662660. 
  • Dubrovskaya V, Lavigne AC, Davidson I, et al. (1996). "Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex.". EMBO J. 15 (14): 3702-12. PMID 8758937. 
  • Rowlands JC, McEwan IJ, Gustafsson JA (1996). "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.". Mol. Pharmacol. 50 (3): 538-48. PMID 8794892. 
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605-10. PMID 8849451. 
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.". Nature 384 (6607): 375-8. doi:10.1038/384375a0. PMID 8934526. 
  • Kojima S, Kobayashi A, Gotoh O, et al. (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor.". J. Biochem. 121 (2): 389-96. PMID 9089417. 
  • Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817-23. PMID 9121429. 
  • McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485-90. PMID 9238003. 
  • Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression.". Biochemistry 36 (34): 10451-62. doi:10.1021/bi971008x. PMID 9265625. 
  • Liang G, Hai T (1997). "Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein.". J. Biol. Chem. 272 (38): 24088-95. PMID 9295363. 
  • Okamoto T, Yamamoto S, Watanabe Y, et al. (1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit.". J. Biol. Chem. 273 (31): 19866-76. PMID 9677423. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD