GTF2A1L

From Wikipedia, the free encyclopedia

TFIIA-alpha/beta-like factor

Identifiers

ALF; MGC26254

External IDs

OMIM: 605358 MGI: 1919078 HomoloGene: 86732

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • transcription coactivator activity • protein binding • transcription initiation factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006872 (mRNA)
NP_006863 (protein)

NM_023630 (mRNA)
NP_076119 (protein)

Location

n/a

Chr 17: 88.58 - 88.62 Mb

Pubmed search

[1]

[2]

TFIIA-alpha/beta-like factor, also known as ALF, is a human gene.^[1]

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.^[1]

[edit] References

^ ^a ^b Entrez Gene: ALF TFIIA-alpha/beta-like factor.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.". Nucleic Acids Res. 24 (14): 2813-20. PMID 8759016.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192-7. PMID 9482861.
Upadhyaya AB, Lee SH, DeJong J (1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis.". J. Biol. Chem. 274 (25): 18040-8. PMID 10364255.
Han SY, Zhou L, Upadhyaya A, et al. (2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse.". Biol. Reprod. 64 (2): 507-17. PMID 11159353.
Yoshida S, Ohbo K, Takakura A, et al. (2002). "Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.". Dev. Biol. 240 (2): 517-30. doi:10.1006/dbio.2001.0473. PMID 11784080.
Xie W, Han S, Khan M, DeJong J (2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation.". J. Biol. Chem. 277 (20): 17765-74. doi:10.1074/jbc.M200954200. PMID 11889132.
Upadhyaya AB, Khan M, Mou TC, et al. (2002). "The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex.". J. Biol. Chem. 277 (37): 34208-16. doi:10.1074/jbc.M204808200. PMID 12107178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Huang M, Wang H, Li J, et al. (2006). "Involvement of ALF in human spermatogenesis and male infertility.". Int. J. Mol. Med. 17 (4): 599-604. PMID 16525715.
Howe ML, Mehmud ZF, Saha S, et al. (2006). "Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo.". Stem Cells Dev. 15 (2): 175-90. doi:10.1089/scd.2006.15.175. PMID 16646664.
Kim M, Li D, Cui Y, et al. (2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene.". J. Biol. Chem. 281 (45): 34288-98. doi:10.1074/jbc.M607168200. PMID 16966320.