GSTT1

From Wikipedia, the free encyclopedia

Glutathione S-transferase theta 1

PDB rendering based on 2c3n.

Available structures: 2c3n, 2c3q, 2c3t

Identifiers

Symbol(s)

GSTT1;

External IDs

OMIM: 600436 MGI: 107379 HomoloGene: 20235

Gene ontology
Molecular Function:	• glutathione transferase activity • transferase activity
Biological Process:	• glutathione metabolic process • response to stress

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000853 (mRNA)
NP_000844 (protein)

NM_008185 (mRNA)
NP_032211 (protein)

Location

Chr 22: 22.71 - 22.71 Mb

Chr 10: 75.23 - 75.24 Mb

Pubmed search

[1]

[2]

Glutathione S-transferase theta 1, also known as GSTT1, is a human gene.

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[1]