GSTP1

From Wikipedia, the free encyclopedia

Glutathione S-transferase pi
PDB rendering based on 10gs.
Available structures: 10gs, 11gs, 12gs, 13gs, 14gs, 16gs, 17gs, 18gs, 19gs, 1aqv, 1aqw, 1aqx, 1eog, 1eoh, 1gss, 1kbn, 1lbk, 1md3, 1md4, 1pgt, 1px6, 1px7, 1zgn, 20gs, 21gs, 22gs, 2a2r, 2a2s, 2gss, 2j9h, 2pgt, 3gss, 3pgt, 4gss, 4pgt, 5gss, 6gss, 7gss, 8gss, 9gss
Identifiers
Symbol(s)	GSTP1; DFN7; FAEES3; GST3; PI
External IDs	OMIM: 134660 MGI: 95864 HomoloGene: 660
Gene ontology Molecular Function: • glutathione transferase activity • protein binding • transferase activity Cellular Component: • cytoplasm Biological Process: • anti-apoptosis • central nervous system development • metabolic process
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2950	14869
Ensembl	ENSG00000084207	ENSMUSG00000038155
Uniprot	P09211	P46425
Refseq	NM_000852 (mRNA) NP_000843 (protein)	NM_181796 (mRNA) NP_861461 (protein)
Location	Chr 11: 67.11 - 67.11 Mb	Chr 19: 4.04 - 4.04 Mb
Pubmed search	[1]	[2]

Glutathione S-transferase pi, also known as GSTP1, is a human gene.

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.^[1]

[edit] References

[edit] Further reading