GSTM4

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Glutathione S-transferase M4
PDB rendering based on 4gtu.
Available structures: 4gtu
Identifiers
Symbol(s) GSTM4; GSTM4-4; GTM4; MGC131945; MGC9247
External IDs OMIM: 138333 MGI: 95862 HomoloGene: 37357
Orthologs
Human Mouse
Entrez 2948 14865
Ensembl n/a ENSMUSG00000027890
Refseq NM_000850 (mRNA)
NP_000841 (protein)		 NM_026764 (mRNA)
NP_081040 (protein)
Location n/a Chr 3: 108.17 - 108.17 Mb
Pubmed search [1] [2]

Glutathione S-transferase M4, also known as GSTM4, is a human gene.[1]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: GSTM4 glutathione S-transferase M4.

[edit] Further reading

  • Bogaards JJ, van Ommen B, van Bladeren PJ (1992). "Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea.". Biochem. J. 286 ( Pt 2): 383–8. PMID 1530570. 
  • Taylor JB, Oliver J, Sherrington R, Pemble SE (1991). "Structure of human glutathione S-transferase class Mu genes.". Biochem. J. 274 ( Pt 2): 587–93. PMID 2006920. 
  • Seidegård J, Vorachek WR, Pero RW, Pearson WR (1988). "Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7293–7. PMID 3174634. 
  • Comstock KE, Widersten M, Hao XY, et al. (1994). "A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.". Arch. Biochem. Biophys. 311 (2): 487–95. doi:10.1006/abbi.1994.1266. PMID 8203914. 
  • Ross VL, Board PG, Webb GC (1994). "Chromosomal mapping of the human Mu class glutathione S-transferases to 1p13.". Genomics 18 (1): 87–91. doi:10.1006/geno.1993.1429. PMID 8276420. 
  • Rozell B, Hansson HA, Guthenberg C, et al. (1994). "Glutathione transferases of classes alpha, mu and pi show selective expression in different regions of rat kidney.". Xenobiotica 23 (8): 835–49. PMID 8284940. 
  • Comstock KE, Johnson KJ, Rifenbery D, Henner WD (1993). "Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4.". J. Biol. Chem. 268 (23): 16958–65. PMID 8349586. 
  • Ross VL, Board PG (1993). "Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.". Biochem. J. 294 ( Pt 2): 373–80. PMID 8373352. 
  • Zhong S, Spurr NK, Hayes JD, Wolf CR (1993). "Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.". Biochem. J. 291 ( Pt 1): 41–50. PMID 8471052. 
  • Patskovsky YV, Patskovska LN, Listowsky I (2000). "An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases.". Biochemistry 38 (49): 16187–94. PMID 10587441. 
  • Beuckmann CT, Fujimori K, Urade Y, Hayaishi O (2000). "Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain.". Neurochem. Res. 25 (5): 733–8. PMID 10905636. 
  • Liloglou T, Walters M, Maloney P, et al. (2003). "A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer.". Lung Cancer 37 (2): 143–6. PMID 12140136. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Denson J, Xi Z, Wu Y, et al. (2006). "Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons.". Gene 379: 148–55. doi:10.1016/j.gene.2006.05.012. PMID 16854533. 
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