GSK3B

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Glycogen synthase kinase 3 beta
PDB rendering based on 1gng.
Available structures: 1gng, 1h8f, 1i09, 1j1b, 1j1c, 1o9u, 1pyx, 1q3d, 1q3w, 1q41, 1q4l, 1q5k, 1r0e, 1uv5
Identifiers
Symbol(s)	GSK3B;
External IDs	OMIM: 605004 MGI: 1861437 HomoloGene: 55629
Gene ontology Molecular Function: • nucleotide binding • glycogen synthase kinase 3 activity • protein binding • ATP binding • transferase activity • NF-kappaB binding Biological Process: • glycogen metabolic process • protein amino acid phosphorylation • Wnt receptor signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2932	56637
Ensembl	ENSG00000082701	ENSMUSG00000022812
Uniprot	P49841	Q3TB31
Refseq	NM_002093 (mRNA) NP_002084 (protein)	NM_019827 (mRNA) NP_062801 (protein)
Location	Chr 3: 121.03 - 121.3 Mb	Chr 16: 38.01 - 38.17 Mb
Pubmed search	[1]	[2]

Glycogen synthase kinase 3 beta, also known as GSK3B, is a human gene.

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992).[supplied by OMIM]^[1]

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