Gs alpha subunit
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GNAS complex locus
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| Identifiers | |
| Symbol | GNAS |
| Alt. Symbols | GNAS1 |
| Entrez | 2778 |
| HUGO | 4392 |
| OMIM | 139320 |
| RefSeq | NM_000516 |
| UniProt | Q5JWF2 |
| Other data | |
| Locus | Chr. 20 q13.2-13.3 |
The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]
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[edit] Receptors
The G-protein coupled receptors that couple to this kind of G-protein include:
- 5-HT receptors types H4 and H7
- ACTH receptor
- Adenosine receptor types A2a and A2b
- Arginine vasopressin receptor 2
- β-adrenergic receptors types β1, β2 and β3
- Calcitonin receptor
- Calcitonin gene-related peptide receptor
- Corticotropin-releasing hormone receptor
- Dopamine receptors D1-like family (D1 and D5)
- FSH-receptor
- Gastric inhibitory polypeptide receptor
- Glucagon receptor
- Histamine H2 receptor
- Luteinizing hormone/choriogonadotropin receptor
- Melanocortin receptor
- Parathyroid hormone receptor 1
- Prostaglandin receptor types D2 and I2
- Secretin receptor
- Thyrotropin receptor
[edit] Function
The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.
[edit] See also
[edit] External links
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