GroES

From Wikipedia, the free encyclopedia

Heat shock 10kDa protein 1 (chaperonin 10)

Identifiers

HSPE1; CPN10; GROES; HSP10

External IDs

OMIM: 600141 MGI: 104680 HomoloGene: 20500

Gene ontology
Molecular Function:	• ATP binding • unfolded protein binding • chaperone binding
Cellular Component:	• mitochondrion
Biological Process:	• protein folding • caspase activation • response to unfolded protein

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002157 (mRNA)
NP_002148 (protein)

NM_008303 (mRNA)
NP_032329 (protein)

Location

Chr 2: 198.07 - 198.08 Mb

Chr 1: 55.03 - 55.04 Mb

Pubmed search

[1]

[2]

Heat shock 10kDa protein 1 (chaperonin 10), also known as HSPE1 or GroES, is a chaperonin which usually works in conjunction with GroEL.^[1] In eukaryotes, it is very similar to Heat Shock Protein 10 or Hsp10.

[edit] References

^ Entrez Gene: HSPE1 heat shock 10kDa protein 1 (chaperonin 10).

[edit] Further reading

Czarnecka AM, Campanella C, Zummo G, Cappello F (2007). "Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?". Cell Stress Chaperones 11 (4): 287-94. PMID 17278877.
Legname G, Fossati G, Gromo G, et al. (1995). "Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10.". FEBS Lett. 361 (2-3): 211-4. PMID 7698325.
Cavanagh AC, Morton H (1994). "The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.". Eur. J. Biochem. 222 (2): 551-60. PMID 7912672.
Monzini N, Legname G, Marcucci F, et al. (1994). "Identification and cloning of human chaperonin 10 homologue.". Biochim. Biophys. Acta 1218 (3): 478-80. PMID 7914093.
Chen JJ, McNealy DJ, Dalal S, Androphy EJ (1994). "Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.". Biochim. Biophys. Acta 1219 (1): 189-90. PMID 7916212.
Samali A, Cai J, Zhivotovsky B, et al. (1999). "Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.". EMBO J. 18 (8): 2040-8. doi:10.1093/emboj/18.8.2040. PMID 10205158.
Summers KM, Fletcher BH, Macaranas DD, et al. (2000). "Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.". Somat. Cell Mol. Genet. 24 (6): 315-26. PMID 10763410.
Richardson A, Schwager F, Landry SJ, Georgopoulos C (2001). "The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.". J. Biol. Chem. 276 (7): 4981-7. doi:10.1074/jbc.M008628200. PMID 11050098.
Fletcher BH, Cassady AI, Summers KM, Cavanagh AC (2001). "The murine chaperonin 10 gene family contains an intronless, putative gene for early pregnancy factor, Cpn10-rs1.". Mamm. Genome 12 (2): 133-40. PMID 11210183.
Parissi V, Calmels C, De Soultrait VR, et al. (2001). "Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.". J. Virol. 75 (23): 11344-53. doi:10.1128/JVI.75.23.11344-11353.2001. PMID 11689615.
Hansen JJ, Dürr A, Cournu-Rebeix I, et al. (2002). "Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.". Am. J. Hum. Genet. 70 (5): 1328-32. PMID 11898127.
Guidry JJ, Wittung-Stafshede P (2002). "Low stability for monomeric human chaperonin protein 10: interprotein interactions contribute majority of oligomer stability.". Arch. Biochem. Biophys. 405 (2): 280-2. PMID 12220543.
Lee KH, Kim HS, Jeong HS, Lee YS (2002). "Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli.". Biochem. Biophys. Res. Commun. 298 (2): 216-24. PMID 12387818.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hansen JJ, Bross P, Westergaard M, et al. (2003). "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.". Hum. Genet. 112 (1): 71-7. doi:10.1007/s00439-002-0837-9. PMID 12483302.
Mansell JP, Yarram SJ, Brown NL, Sandy JR (2004). "Type I collagen synthesis by human osteoblasts in response to placental lactogen and chaperonin 10, a homolog of early-pregnancy factor.". In Vitro Cell. Dev. Biol. Anim. 38 (9): 518-22. PMID 12703979.
Cappello F, Bellafiore M, David S, et al. (2003). "Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.". Cancer Lett. 196 (1): 35-41. PMID 12860287.
Shan YX, Liu TJ, Su HF, et al. (2004). "Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.". J. Mol. Cell. Cardiol. 35 (9): 1135-43. PMID 12967636.
Shan YX, Yang TL, Mestril R, Wang PH (2003). "Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.". J. Biol. Chem. 278 (46): 45492-8. doi:10.1074/jbc.M304498200. PMID 12970367.
Guidry JJ, Shewmaker F, Maskos K, et al. (2004). "Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified.". BMC Biochem. 4: 14. doi:10.1186/1471-2091-4-14. PMID 14525625.