GRK4

From Wikipedia, the free encyclopedia

G protein-coupled receptor kinase 4

Identifiers

GRK4; GPRK2L; GPRK4; GRK4a; IT11

External IDs

OMIM: 137026 MGI: 95801 HomoloGene: 23158

Gene ontology
Molecular Function:	• nucleotide binding • G-protein coupled receptor kinase activity • signal transducer activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • signal transduction • regulation of G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001128361 (mRNA)
XP_001128361 (protein)

NM_001080743 (mRNA)
NP_001074212 (protein)

Location

Chr 4: 2.94 - 3.01 Mb

Chr 5: 34.98 - 35.07 Mb

Pubmed search

[1]

[2]

G protein-coupled receptor kinase 4, also known as GRK4, is a human gene.^[1]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRK4 G protein-coupled receptor kinase 4.

[edit] Further reading

Ambrose C, James M, Barnes G, et al. (1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3.". Hum. Mol. Genet. 1 (9): 697–703. PMID 1338872.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Sallese M, Lombardi MS, De Blasi A (1994). "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning.". Biochem. Biophys. Res. Commun. 199 (2): 848–54. PMID 8135832.
Premont RT, Macrae AD, Stoffel RH, et al. (1996). "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.". J. Biol. Chem. 271 (11): 6403–10. PMID 8626439.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Sallese M, Mariggiò S, Collodel G, et al. (1997). "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells.". J. Biol. Chem. 272 (15): 10188–95. PMID 9092566.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lazari MF, Liu X, Nakamura K, et al. (1999). "Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.". Mol. Endocrinol. 13 (6): 866–78. PMID 10379886.
Blaukat A, Pizard A, Breit A, et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
Watanabe H, Xu J, Bengra C, et al. (2003). "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4.". Kidney Int. 62 (3): 790–8. doi:10.1046/j.1523-1755.2002.00525.x. PMID 12164861.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Perroy J, Adam L, Qanbar R, et al. (2003). "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4.". EMBO J. 22 (15): 3816–24. doi:10.1093/emboj/cdg383. PMID 12881416.
Speirs HJ, Katyk K, Kumar NN, et al. (2004). "Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.". J. Hypertens. 22 (5): 931–6. PMID 15097232.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rankin ML, Marinec PS, Cabrera DM, et al. (2006). "The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4.". Mol. Pharmacol. 69 (3): 759–69. doi:10.1124/mol.105.019901. PMID 16338988.
Zhu H, Lu Y, Wang X, et al. (2006). "The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins.". Am. J. Hypertens. 19 (1): 61–6. doi:10.1016/j.amjhyper.2005.07.007. PMID 16461192.
Zhu H, Lu Y, Wang X, et al. (2006). "The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents.". Pediatr. Res. 60 (4): 440–2. doi:10.1203/01.pdr.0000238250.64591.44. PMID 16940246.
Wang Y, Li B, Zhao W, et al. (2006). "Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.". Ann. Hum. Genet. 70 (Pt 6): 778–83. doi:10.1111/j.1469-1809.2006.00278.x. PMID 17044852.
Wang Z, Armando I, Asico LD, et al. (2007). "The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production.". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2083–92. doi:10.1152/ajpheart.00944.2006. PMID 17259440.