Talk:Grignard reaction

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A well written and informative piece.

It provides helpful background information and practical tips.

However, I think some safety information would strengthen it.
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how do you convert acid halide to secondary alcohal by reaction with Grignard reagent??

That can't be done as you describe it. When a Grignard reacts with an acyl halide, a ketone is formed. Usually, a second molecule of the Grignard agent will then react with the carbonyl, giving a tertiary alcohol. If you could prevent this second reaction, you could reduce the ketone to a secondary alcohol, but doing so is hard for acyl halides and the reduction isn't a Grignard reaction. Or you could reduce the acyl halide to an aldehyde and then Grignard rxn would give secondary alcohol, but again, reduction ≠ Grignard. DMacks 05:55, 8 March 2006 (UTC)

Contents

[edit] Clean up

In think that in the hast to do the clean up that the article has been harmed by the removal of details of reactions with non-carbon electrophiles such as SnCl4. These are as much a part of Grignard chemistry as the reaction of the 'organic' carbon based electrophiles.Cadmium

So I did. Oops. I'll try to get to putting those back in either tonight or tomorrow. However, if you want to do it, go right ahead. ~K 15:42, 31 July 2006 (UTC)
You might also want to add NaBF4 + 4 RMgX to form Na BR4, this this the basics of how to make BPh4 anions.Cadmium
You beat me to it and did a much better job than I had planned. Thanks. ~K 17:23, 5 August 2006 (UTC)

[edit] Chemical drawing needed

What exactly is missing? --Rifleman 82 00:18, 13 September 2007 (UTC)

Image:OrganoelementGrignard.png is a red link, I don't know if someone had intended to upload something but forgot, or what. shoy 19:51, 13 September 2007 (UTC)

[edit] Couplingis severly wrong

nonylmagnesium bromide reacts with an aryl chloride to a nonyl benzoic acid This is not whats in the mentioned literature whic is the production of carboxylic acids by the reaction of Grignard reaction with carbondioxide.--Stone (talk) 10:21, 8 February 2008 (UTC)

doi:10.1016/S0022-328X(96)06794-0  might be a better ref.--Stone (talk) 10:25, 8 February 2008 (UTC)
Further more the reaction itself is not a very good example because the Grignard would normaly go for the ester group and not for the bromine. JACS 1948 This has to be pointed out! --Stone (talk) 10:31, 8 February 2008 (UTC)

[edit] An extra reaction

Might want to include the reaction with a di ester (e.g. (EtO)2 C=O) Its an interesting reaction, and has applications in dye manufacture for making crystal violet[1] 129.67.121.34 (talk) 13:46, 17 February 2008 (UTC) Will