GRIPAP1

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GRIP1 associated protein 1
Identifiers
Symbol(s) GRIPAP1; DKFZp434P0630; GRASP-1; KIAA1167; MGC126593; MGC126595
External IDs OMIM: 300408 MGI: 1859616 HomoloGene: 41348
Orthologs
Human Mouse
Entrez 56850 54645
Ensembl ENSG00000068400 ENSMUSG00000031153
Uniprot Q4V328 Q8VD04
Refseq NM_020137 (mRNA)
NP_064522 (protein)		 NM_207670 (mRNA)
NP_997553 (protein)
Location Chr X: 48.72 - 48.74 Mb Chr X: 6.95 - 6.98 Mb
Pubmed search [1] [2]

GRIP1 associated protein 1, also known as GRIPAP1, is a human gene.[1]

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: GRIPAP1 GRIP1 associated protein 1.

[edit] Further reading

  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461. 
  • Ye B, Liao D, Zhang X, et al. (2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.". Neuron 26 (3): 603-17. PMID 10896157. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.". J. Biol. Chem. 277 (4): 2396-405. doi:10.1074/jbc.M106312200. PMID 11704662. 
  • Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221-4. doi:10.1074/jbc.C200112200. PMID 11891216. 
  • Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody.". Neuroscience 114 (1): 217-27. PMID 12207967. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading.". J. Cell. Sci. 116 (Pt 5): 897-906. PMID 12571287. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Nakata A, Ito T, Nagata M, et al. (2005). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1.". Genes Cells 9 (11): 1125-35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651. 
  • Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes.". Clin. Immunol. 116 (2): 108-17. doi:10.1016/j.clim.2005.03.021. PMID 15897011. 
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