GRIN3B

From Wikipedia, the free encyclopedia

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B

Identifiers

External IDs

OMIM: 606651 MGI: 2150393 HomoloGene: 15606

Gene ontology
Molecular Function:	• magnesium ion binding • receptor activity • ionotropic glutamate receptor activity • ion channel activity • extracellular-glutamate-gated ion channel activity • calcium channel activity • calcium ion binding
Cellular Component:	• membrane • integral to membrane • N-methyl-D-aspartate selective glutamate receptor complex • cell soma • postsynaptic membrane
Biological Process:	• ion transport • protein insertion into membrane • regulation of calcium ion transport

Orthologs

Human

Mouse

Refseq

NM_138690 (mRNA)
NP_619635 (protein)

NM_130455 (mRNA)
NP_569722 (protein)

Location

Chr 19: 0.95 - 0.96 Mb

Chr 10: 79.37 - 79.38 Mb

Pubmed search

[1]

[2]

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B, also known as GRIN3B, is a human gene.^[1]

[edit] References

^ Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B.

[edit] Further reading

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Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.". Science 269 (5231): 1737–40. PMID 7569905.
Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.
Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.". Eur. J. Neurosci. 7 (11): 2285–93. PMID 8563977.
Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 4 (3): 315–21. PMID 8581564.
Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.". AIDS 10 (5): 463–8. PMID 8724036.
Wu P, Price P, Du B, et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.". Neuroreport 7 (5): 1045–9. PMID 8804048.
Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.". Brain Res. 705 (1-2): 168–76. PMID 8821747.
Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.". Brain Res. 706 (2): 303–7. PMID 8822372.
Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.". Eur. J. Neurosci. 7 (12): 2502–7. PMID 8845955.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Raber J, Toggas SM, Lee S, et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.". Virology 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.
New DR, Maggirwar SB, Epstein LG, et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.". J. Biol. Chem. 273 (28): 17852–8. PMID 9651389.
Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.". Neuroscience 88 (2): 585–97. PMID 10197777.
Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428.
Xin KQ, Hamajima K, Hattori S, et al. (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.". AIDS Res. Hum. Retroviruses 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.
Haughey NJ, Nath A, Mattson MP, et al. (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity.". J. Neurochem. 78 (3): 457–67. PMID 11483648.
Bonavia R, Bajetto A, Barbero S, et al. (2001). "HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.". Biochem. Biophys. Res. Commun. 288 (2): 301–8. doi:10.1006/bbrc.2001.5743. PMID 11606043.
Nishi M, Hinds H, Lu HP, et al. (2002). "Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner.". J. Neurosci. 21 (23): RC185. PMID 11717388.