GRIK3

From Wikipedia, the free encyclopedia

Glutamate receptor, ionotropic, kainate 3

Identifiers

GRIK3; EAA5; GLR7; GLUR7; GluR7a

External IDs

OMIM: 138243 MGI: 95816 HomoloGene: 73901

Gene ontology
Molecular Function:	• receptor activity • ionotropic glutamate receptor activity • ion channel activity • extracellular-glutamate-gated ion channel activity • kainate selective glutamate receptor activity
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane • postsynaptic membrane
Biological Process:	• ion transport • glutamate signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_000831 (mRNA)
NP_000822 (protein)

XM_131647 (mRNA)
XP_131647 (protein)

Location

Chr 1: 37.03 - 37.27 Mb

Chr 4: 125.13 - 125.21 Mb

Pubmed search

[1]

[2]

Glutamate receptor, ionotropic, kainate 3, also known as GRIK3, is a human gene.^[1]

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Kainate receptor

[edit] References

^ ^a ^b Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3.

[edit] Further reading

Nutt SL, Hoo KH, Rampersad V, et al. (1995). "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.". Recept. Channels 2 (4): 315-26. PMID 7719709.
Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (1994). "Chromosomal localization of gene for human glutamate receptor subunit-7.". Somat. Cell Mol. Genet. 19 (6): 581-8. PMID 8128318.
Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679-82. PMID 8163463.
Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485-97. PMID 9466455.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Schiffer HH, Swanson GT, Masliah E, Heinemann SF (2001). "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.". J. Neurosci. 20 (24): 9025-33. PMID 11124978.
Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.". FEBS Lett. 514 (2-3): 184-8. PMID 11943148.
Begni S, Popoli M, Moraschi S, et al. (2002). "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.". Mol. Psychiatry 7 (4): 416-8. doi:10.1038/sj.mp.4000987. PMID 11986986.
Delorme R, Krebs MO, Chabane N, et al. (2004). "Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.". Neuroreport 15 (4): 699-702. PMID 15094479.
Preuss UW, Zill P, Koller G, et al. (2006). "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics.". Pharmacogenomics J. 6 (1): 34-41. doi:10.1038/sj.tpj.6500343. PMID 16314883.
Samochowiec J, Grzywacz A, Kucharska-Mazur J, et al. (2006). "Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence.". Neurosci. Lett. 396 (2): 159-62. doi:10.1016/j.neulet.2005.11.030. PMID 16356644.
Schiffer HH, Heinemann SF (2007). "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 20-6. doi:10.1002/ajmg.b.30374. PMID 16958029.
Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags.". DNA Res. 13 (6): 275-86. doi:10.1093/dnares/dsl016. PMID 17213182.

[edit] External links

MeSH GRIK3+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Ion channel, receptor: ligand-gated ion channels

Cys-loop receptors	5-HT/serotonin: 5-HT₃ (A) GABA: GABA A (α₁, α₂, α₃, α₄, α₅, α₆, β₁, β₂, β₃, γ₂, γ₃, δ, ε, π), GABA C (ρ₁, ρ₂) Glycine: α₁, α₂, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)₂(β2)₃, (α7)₅, Ganglion type, Muscle type)

Ionotropic glutamates	AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)

ATP-gated channels	Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)