GRIK2

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Glutamate receptor, ionotropic, kainate 2
PDB rendering based on 1s50.
Available structures: 1s50, 1s7y, 1s9t, 1sd3, 1tt1, 1yae, 2i0b, 2i0c
Identifiers
Symbol(s) GRIK2; EAA4; GLR6; GLUR6; MGC74427
External IDs OMIM: 138244 MGI: 95815 HomoloGene: 40717
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2898 14806
Ensembl ENSG00000164418 ENSMUSG00000056073
Uniprot Q13002 P39087
Refseq NM_021956 (mRNA)
NP_068775 (protein)		 NM_010349 (mRNA)
NP_034479 (protein)
Location Chr 6: 101.95 - 102.62 Mb Chr 10: 48.79 - 49.47 Mb
Pubmed search [1] [2]

Glutamate receptor, ionotropic, kainate 2, also known as GRIK2, is a human gene.[1]

This gene encodes a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity and may be important for learning and memory. It also may be involved in the transmission of light information from the retina to the hypothalamus. The structure and function of the encoded protein is changed by RNA editing. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: GRIK2 glutamate receptor, ionotropic, kainate 2.

[edit] Further reading

  • Seeburg PH, Higuchi M, Sprengel R (1998). "RNA editing of brain glutamate receptor channels: mechanism and physiology.". Brain Res. Brain Res. Rev. 26 (2-3): 217–29. PMID 9651532. 
  • Paschen W, Hedreen JC, Ross CA (1994). "RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.". J. Neurochem. 63 (5): 1596–602. PMID 7523595. 
  • Hoo KH, Nutt SL, Fletcher EJ, et al. (1995). "Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.". Recept. Channels 2 (4): 327–37. PMID 7536611. 
  • Sander T, Janz D, Ramel C, et al. (1995). "Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies.". Neurology 45 (9): 1713–20. PMID 7675232. 
  • Nutt SL, Kamboj RK (1995). "RNA editing of human kainate receptor subunits.". Neuroreport 5 (18): 2625–9. PMID 7696618. 
  • Paschen W, Blackstone CD, Huganir RL, Ross CA (1994). "Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment.". Genomics 20 (3): 435–40. doi:10.1006/geno.1994.1198. PMID 8034316. 
  • Raymond LA, Blackstone CD, Huganir RL (1993). "Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.". Nature 361 (6413): 637–41. doi:10.1038/361637a0. PMID 8094892. 
  • Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6.". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463. 
  • Taverna FA, Wang LY, MacDonald JF, Hampson DR (1994). "A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.". J. Biol. Chem. 269 (19): 14159–64. PMID 8188697. 
  • Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.". J. Biol. Chem. 269 (2): 1332–9. PMID 8288598. 
  • Pickering DS, Taverna FA, Salter MW, Hampson DR (1996). "Palmitoylation of the GluR6 kainate receptor.". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12090–4. PMID 8618850. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.". Brain Res. 751 (2): 217–31. PMID 9099808. 
  • Rubinsztein DC, Leggo J, Chiano M, et al. (1997). "Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3872–6. PMID 9108071. 
  • Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. PMID 9466455. 
  • Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. PMID 9808460. 
  • Leuschner WD, Hoch W (1999). "Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.". J. Biol. Chem. 274 (24): 16907–16. PMID 10358037. 
  • Smith HJ (2001). "The introduction of MR in the Nordic countries with special reference to Norway: central control versus local initiatives.". Journal of magnetic resonance imaging : JMRI 13 (4): 639–44. PMID 11276111. 
  • Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111. 

[edit] External links

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v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
Ionotropic glutamates
AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)
ATP-gated channels