GRID2

From Wikipedia, the free encyclopedia

Glutamate receptor, ionotropic, delta 2

Identifiers

GRID2; MGC117022; MGC117023; MGC117024

External IDs

OMIM: 602368 MGI: 95813 HomoloGene: 74399

Gene ontology
Molecular Function:	• receptor activity • ionotropic glutamate receptor activity • ion channel activity • extracellular-glutamate-gated ion channel activity • protein binding
Cellular Component:	• integral to plasma membrane • membrane • synaptosome • postsynaptic membrane
Biological Process:	• ion transport • glutamate signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001510 (mRNA)
NP_001501 (protein)

XM_989862 (mRNA)
XP_994956 (protein)

Location

Chr 4: 93.44 - 94.91 Mb

Chr 6: 63.19 - 64.6 Mb

Pubmed search

[1]

[2]

Glutamate receptor, ionotropic, delta 2, also known as GRID2, is a human gene.^[1]

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRID2 glutamate receptor, ionotropic, delta 2.

[edit] Further reading

Araki K, Meguro H, Kushiya E, et al. (1994). "Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells.". Biochem. Biophys. Res. Commun. 197 (3): 1267–76. doi:10.1006/bbrc.1993.2614. PMID 7506541.
Hu W, Zuo J, De Jager PL, Heintz N (1998). "The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22.". Genomics 47 (1): 143–5. doi:10.1006/geno.1997.5108. PMID 9465309.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Roche KW, Ly CD, Petralia RS, et al. (1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses.". J. Neurosci. 19 (10): 3926–34. PMID 10234023.
Hironaka K, Umemori H, Tezuka T, et al. (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.
Miyagi Y, Yamashita T, Fukaya M, et al. (2002). "Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.". J. Neurosci. 22 (3): 803–14. PMID 11826110.
Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein.". Biochem. Biophys. Res. Commun. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.
Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.". Neuron 35 (5): 921–33. PMID 12372286.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kohda K, Kamiya Y, Matsuda S, et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.". Brain Res. Mol. Brain Res. 110 (1): 27–37. PMID 12573530.
Yap CC, Muto Y, Kishida H, et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. PMID 12589829.
Sonoda T, Mochizuki C, Yamashita T, et al. (2006). "Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.". Biochem. Biophys. Res. Commun. 350 (3): 748–52. doi:10.1016/j.bbrc.2006.09.109. PMID 17027646.