GRIA3

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Glutamate receptor, ionotrophic, AMPA 3
Identifiers
Symbol(s) GRIA3; GLUR-K3; GLUR3; GLURC; gluR-C
External IDs OMIM: 305915 MGI: 95810 HomoloGene: 37353
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2892 53623
Ensembl ENSG00000125675 ENSMUSG00000001986
Uniprot P42263 Q0VGS8
Refseq NM_000828 (mRNA)
NP_000819 (protein)		 NM_016886 (mRNA)
NP_058582 (protein)
Location Chr X: 122.15 - 122.45 Mb Chr X: 37.65 - 37.92 Mb
Pubmed search [1] [2]

Glutamate receptor, ionotrophic, AMPA 3, also known as GRIA3, is a human gene.[1]

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternative splicing at this locus results in several different isoforms which may vary in their signal transduction properties.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3.

[edit] Further reading

  • McNamara JO, Eubanks JH, McPherson JD, et al. (1992). "Chromosomal localization of human glutamate receptor genes.". J. Neurosci. 12 (7): 2555–62. PMID 1319477. 
  • Hollmann M, Hartley M, Heinemann S (1991). "Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition.". Science 252 (5007): 851–3. PMID 1709304. 
  • Rampersad V, Elliott CE, Nutt SL, et al. (1994). "Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins.". Biochim. Biophys. Acta 1219 (2): 563–6. PMID 7918660. 
  • Rogers SW, Andrews PI, Gahring LC, et al. (1994). "Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis.". Science 265 (5172): 648–51. PMID 8036512. 
  • Tomiyama M, Rodriguez-Puertas R, Cortés R, et al. (1997). "Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization.". Neuroscience 75 (3): 901–15. PMID 8951883. 
  • Osten P, Srivastava S, Inman GJ, et al. (1998). "The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs.". Neuron 21 (1): 99–110. PMID 9697855. 
  • Srivastava S, Osten P, Vilim FS, et al. (1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP.". Neuron 21 (3): 581–91. PMID 9768844. 
  • Hayashi T, Umemori H, Mishina M, Yamamoto T (1999). "The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn.". Nature 397 (6714): 72–6. doi:10.1038/16269. PMID 9892356. 
  • Amir R, Dahle EJ, Toriolo D, Zoghbi HY (2000). "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.". Am. J. Med. Genet. 90 (1): 69–71. PMID 10602120. 
  • Gécz J, Barnett S, Liu J, et al. (2000). "Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.". Genomics 62 (3): 356–68. doi:10.1006/geno.1999.6032. PMID 10644433. 
  • Aruscavage PJ, Bass BL (2000). "A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing.". RNA 6 (2): 257–69. PMID 10688364. 
  • Gahring L, Carlson NG, Meyer EL, Rogers SW (2001). "Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation.". J. Immunol. 166 (3): 1433–8. PMID 11160179. 
  • Liu QJ, Gong YQ, Chen BX, et al. (2001). "[Linkage analysis and mutation detection of GRIA3 in Smith--Fineman--Myers syndrome]". Yi Chuan Xue Bao 28 (11): 985–90. PMID 11725645. 
  • Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216. 
  • Wyszynski M, Kim E, Dunah AW, et al. (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.". Neuron 34 (1): 39–52. PMID 11931740. 
  • Tomiyama M, Rodríguez-Puertas R, Cortés R, et al. (2002). "Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis.". Synapse 45 (4): 245–9. doi:10.1002/syn.10098. PMID 12125045. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ganor Y, Besser M, Ben-Zakay N, et al. (2003). "Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.". J. Immunol. 170 (8): 4362–72. PMID 12682273. 
  • Flajolet M, Rakhilin S, Wang H, et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMID 14663150. 
  • Kolleker A, Zhu JJ, Schupp BJ, et al. (2004). "Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.". Neuron 40 (6): 1199–212. PMID 14687553. 

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v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
Ionotropic glutamates
AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D)
ATP-gated channels