GRHPR

From Wikipedia, the free encyclopedia

Glyoxylate reductase/hydroxypyruvate reductase

PDB rendering based on 2gcg.

Available structures: 2gcg, 2h1s

Identifiers

Symbol(s)

GRHPR; PH2; GLXR

External IDs

OMIM: 604296 MGI: 1923488 HomoloGene: 49088

Gene ontology
Molecular Function:	• protein binding • glycerate dehydrogenase activity • oxidoreductase activity • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • hydroxypyruvate reductase activity • glyoxylate reductase (NADP) activity • NAD binding
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• electron transport • L-serine biosynthetic process • excretion • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012203 (mRNA)
NP_036335 (protein)

NM_080289 (mRNA)
NP_525028 (protein)

Location

Chr 9: 37.41 - 37.43 Mb

Chr 4: 45 - 45.01 Mb

Pubmed search

[1]

[2]

Glyoxylate reductase/hydroxypyruvate reductase, also known as GRHPR, is a human gene.^[1]

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase.

[edit] Further reading

Takayama T, Nagata M, Ozono S, et al. (2007). "A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2.". Nephrol. Dial. Transplant. 22 (8): 2371–4. doi:10.1093/ndt/gfm271. PMID 17510093.
Booth MP, Conners R, Rumsby G, Brady RL (2006). "Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase.". J. Mol. Biol. 360 (1): 178–89. doi:10.1016/j.jmb.2006.05.018. PMID 16756993.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Webster KE, Ferree PM, Holmes RP, Cramer SD (2000). "Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2).". Hum. Genet. 107 (2): 176–85. PMID 11030416.
Huang T, Yang W, Pereira AC, et al. (2000). "Cloning and characterization of a putative human d-2-hydroxyacid dehydrogenase in chromosome 9q.". Biochem. Biophys. Res. Commun. 268 (2): 298–301. doi:10.1006/bbrc.2000.2122. PMID 10679197.
Rumsby G, Cregeen DP (1999). "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase.". Biochim. Biophys. Acta 1446 (3): 383–8. PMID 10524214.
Cramer SD, Ferree PM, Lin K, et al. (1999). "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.". Hum. Mol. Genet. 8 (11): 2063–9. PMID 10484776.