GRB14

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Growth factor receptor-bound protein 14
PDB rendering based on 2aug.
Available structures: 2aug, 2auh
Identifiers
Symbol(s) GRB14;
External IDs OMIM: 601524 MGI: 1355324 HomoloGene: 3303
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2888 50915
Ensembl ENSG00000115290 ENSMUSG00000026888
Uniprot Q14449 Q9JLM9
Refseq XM_001131269 (mRNA)
XP_001131269 (protein)		 NM_016719 (mRNA)
NP_057928 (protein)
Location Chr 2: 165.06 - 165.19 Mb Chr 2: 64.71 - 64.82 Mb
Pubmed search [1] [2]

Growth factor receptor-bound protein 14, also known as GRB14, is a human gene.[1]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[1]

[edit] References

  1. ^ a b Entrez Gene: GRB14 growth factor receptor-bound protein 14.

[edit] Further reading

  • Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions.". Oncogene 20 (44): 6315–21. doi:10.1038/sj.onc.1204775. PMID 11607834. 
  • Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family.". J. Biol. Chem. 271 (21): 12502–10. PMID 8647858. 
  • Baker E, Sutherland GR, Sutherland RL, Daly RJ (1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization.". Genomics 36 (1): 218–20. doi:10.1006/geno.1996.0453. PMID 8812444. 
  • Kasus-Jacobi A, Perdereau D, Auzan C, et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions.". J. Biol. Chem. 273 (40): 26026–35. PMID 9748281. 
  • Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896–905. PMID 10521483. 
  • Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner.". J. Biol. Chem. 275 (11): 7771–8. PMID 10713090. 
  • Hemming R, Agatep R, Badiani K, et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins.". Biochem. Cell Biol. 79 (1): 21–32. PMID 11235915. 
  • Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563. 
  • Béréziat V, Kasus-Jacobi A, Perdereau D, et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.". J. Biol. Chem. 277 (7): 4845–52. doi:10.1074/jbc.M106574200. PMID 11726652. 
  • Cariou B, Perdereau D, Cailliau K, et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.". Mol. Cell. Biol. 22 (20): 6959–70. PMID 12242277. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.". J. Biol. Chem. 279 (36): 37518–27. doi:10.1074/jbc.M405340200. PMID 15210700. 
  • Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain.". Protein Sci. 13 (9): 2541–6. doi:10.1110/ps.04884704. PMID 15322292. 
  • Kairouz R, Parmar J, Lyons RJ, et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Depetris RS, Hu J, Gimpelevich I, et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.". Mol. Cell 20 (2): 325–33. doi:10.1016/j.molcel.2005.09.001. PMID 16246733. 
  • Park JJ, Berggren JR, Hulver MW, et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.". Physiol. Genomics 27 (2): 114–21. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634. 
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