GRB10

From Wikipedia, the free encyclopedia


Growth factor receptor-bound protein 10
PDB rendering based on 1nrv.
Available structures: 1nrv
Identifiers
Symbol(s) GRB10; GRB-IR; IRBP; KIAA0207; MEG1; RSS
External IDs OMIM: 601523 MGI: 103232 HomoloGene: 3882
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2887 14783
Ensembl ENSG00000106070 ENSMUSG00000020176
Uniprot Q13322 Q3TFU9
Refseq NM_001001549 (mRNA)
NP_001001549 (protein)		 NM_010345 (mRNA)
NP_034475 (protein)
Location Chr 7: 50.63 - 50.83 Mb Chr 11: 11.83 - 11.94 Mb
Pubmed search [1] [2]

Growth factor receptor-bound protein 10, also known as GRB10, is a human gene.[1]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

[edit] References

  1. ^ a b Entrez Gene: GRB10 growth factor receptor-bound protein 10.

[edit] Further reading

  • Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H (1992). "Severe Silver-Russell syndrome and translocation (17;20) (q25;q13)". Clin. Genet. 41 (1): 51–3. PMID 1633648. 
  • Liu F, Roth RA (1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10287–91. PMID 7479769. 
  • Pandey A, Duan H, Di Fiore PP, Dixit VM (1995). "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10.". J. Biol. Chem. 270 (37): 21461–3. PMID 7665556. 
  • Midro AT, Debek K, Sawicka A, et al. (1993). "Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25.". Clin. Genet. 44 (1): 53–5. PMID 8403458. 
  • Hansen H, Svensson U, Zhu J, et al. (1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.". J. Biol. Chem. 271 (15): 8882–6. PMID 8621530. 
  • Morrione A, Valentinis B, Li S, et al. (1996). "Grb10: A new substrate of the insulin-like growth factor I receptor.". Cancer Res. 56 (14): 3165–7. PMID 8764099. 
  • O'Neill TJ, Rose DW, Pillay TS, et al. (1996). "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.". J. Biol. Chem. 271 (37): 22506–13. PMID 8798417. 
  • Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.". J. Biol. Chem. 271 (38): 23588–93. PMID 8798570. 
  • Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.". J. Biol. Chem. 272 (5): 2659–67. PMID 9006901. 
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502. 
  • Jerome CA, Scherer SW, Tsui LC, et al. (1997). "Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12.". Genomics 40 (1): 215–6. doi:10.1006/geno.1996.4535. PMID 9070953. 
  • Dong LQ, Du H, Porter SG, et al. (1997). "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.". J. Biol. Chem. 272 (46): 29104–12. PMID 9360986. 
  • He W, Rose DW, Olefsky JM, Gustafson TA (1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains.". J. Biol. Chem. 273 (12): 6860–7. PMID 9506989. 
  • Nantel A, Mohammad-Ali K, Sherk J, et al. (1998). "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.". J. Biol. Chem. 273 (17): 10475–84. PMID 9553107. 
  • Moutoussamy S, Renaudie F, Lago F, et al. (1998). "Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.". J. Biol. Chem. 273 (26): 15906–12. PMID 9632636. 
  • Bai RY, Jahn T, Schrem S, et al. (1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL.". Oncogene 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873. 
  • Mano H, Ohya K, Miyazato A, et al. (1998). "Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.". Genes Cells 3 (7): 431–41. PMID 9753425. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074. 
  • Angrist M, Bolk S, Bentley K, et al. (1999). "Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease.". Oncogene 17 (23): 3065–70. doi:10.1038/sj.onc.1202226. PMID 9881709. 
  • Wang J, Dai H, Yousaf N, et al. (1999). "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.". Mol. Cell. Biol. 19 (9): 6217–28. PMID 10454568. 

[edit] External links

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Cell signaling: carrier proteins: adaptor proteins
STAT
Interferon regulatory factors
Growth factor receptor-bound protein
GRB2 - GRB7 - GRB10
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