Granulosa cell tumour
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| Granulosa cell tumour Classification and external resources |
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| ICD-10 | C56. |
|---|---|
| ICD-9 | 183 |
| ICD-O: | 8620 |
| eMedicine | med/928 |
| MeSH | D006106 |
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This article may require cleanup to meet Wikipedia's quality standards. Please improve this article if you can. (September 2007) |
Granulosa cell tumo(u)rs (or granulosa-theca cell tumo(u)rs) are tumors of the granulosa cell. They are part of the sex cord-stromal tumour group of ovarian neoplasms.
The peak age at which they occur is 50-55 years, but they may occur at any age.
[edit] Clinical presentation
Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age.
- If the patient is postmenopausal, she usually presents with abnormal uterine bleeding.
- If the patient is of reproductive age, she would present with menometrorrhagia. However, in some cases she may stop ovulating altogether.
- If the patient has not undergone puberty, isosexual-pseudo-precocity may be seen.
[edit] Histology
The most characteristic gross appearance is a smooth surfaced solid and cystic lesion with the cysts filled with blood. Hemoperitoneum is an infrequent but classical presentation. A large variety of histological presentations exists, but they have two key features:
- Call-Exner bodies (granulosa cells arranged haphazardly around a space containing eosinophilic fluid); and
- Pale uniform nuclei, often with grooves
There have been cases where the tumor presented as a single, cyst-like, space, with no internal bleeding.
[edit] External links
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