GRAP

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GRB2-related adaptor protein

Identifiers

Symbol(s)

GRAP; MGC64880

External IDs

OMIM: 604330 MGI: 1918770 HomoloGene: 4822

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity
Cellular Component:	• cytoplasm
Biological Process:	• intracellular signaling cascade • Ras protein signal transduction • cell-cell signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001132900 (mRNA)
XP_001132900 (protein)

XM_001005586 (mRNA)
XP_001005586 (protein)

Location

Chr 17: 18.86 - 18.89 Mb

Chr 11: 61.47 - 61.49 Mb

Pubmed search

[1]

[2]

GRB2-related adaptor protein, also known as GRAP, is a human gene.^[1]

This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRAP GRB2-related adaptor protein.

[edit] Further reading

Feng GS, Ouyang YB, Hu DP, et al. (1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway.". J. Biol. Chem. 271 (21): 12129-32. PMID 8647802.
Trüb T, Frantz JD, Miyazaki M, et al. (1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.". J. Biol. Chem. 272 (2): 894-902. PMID 8995379.
Welsh M, Songyang Z, Frantz JD, et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.". Oncogene 16 (7): 891-901. doi:10.1038/sj.onc.1201607. PMID 9484780.
Zhang W, Sloan-Lancaster J, Kitchen J, et al. (1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.". Cell 92 (1): 83-92. PMID 9489702.
Wenzel J, Sanzenbacher R, Ghadimi M, et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.". FEBS Lett. 509 (2): 255-62. PMID 11741599.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhao C, Ma H, Bossy-Wetzel E, et al. (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.". J. Biol. Chem. 278 (36): 34641-53. doi:10.1074/jbc.M304594200. PMID 12819203.
Shiraiwa H, Takei M, Yoshikawa T, et al. (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.". J. Int. Med. Res. 32 (3): 284-91. PMID 15174222.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.