GRAP2

From Wikipedia, the free encyclopedia

GRB2-related adaptor protein 2

PDB rendering based on 1h3h.

Available structures: 1h3h, 1oeb, 1r1p, 1r1q, 1r1s, 1uti, 2d0n

Identifiers

Symbol(s)

GRAP2; P38; GADS; GRAP-2; GRB2L; GRBLG; GRID; GRPL; GrbX; Grf40; Mona

External IDs

OMIM: 604518 MGI: 1333842 HomoloGene: 21007

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• intracellular signaling cascade • Ras protein signal transduction • cell-cell signaling • antimicrobial humoral response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004810 (mRNA)
NP_004801 (protein)

XM_001002330 (mRNA)
XP_001002330 (protein)

Location

Chr 22: 38.63 - 38.7 Mb

Chr 15: 80.4 - 80.48 Mb

Pubmed search

[1]

[2]

GRB2-related adaptor protein 2, also known as GRAP2, is a human gene.^[1]

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: GRAP2 GRB2-related adaptor protein 2.

[edit] Further reading

Bourette RP, Arnaud S, Myles GM, et al. (1999). "Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.". EMBO J. 17 (24): 7273–81. doi:10.1093/emboj/17.24.7273. PMID 9857184.
Liu SK, McGlade CJ (1999). "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.". Oncogene 17 (24): 3073–82. doi:10.1038/sj.onc.1202337. PMID 9872323.
Qiu M, Hua S, Agrawal M, et al. (1999). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1.". Biochem. Biophys. Res. Commun. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555.
Liu SK, Fang N, Koretzky GA, McGlade CJ (1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.". Curr. Biol. 9 (2): 67–75. PMID 10021361.
Law CL, Ewings MK, Chaudhary PM, et al. (1999). "GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.". J. Exp. Med. 189 (8): 1243–53. PMID 10209041.
Asada H, Ishii N, Sasaki Y, et al. (1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.". J. Exp. Med. 189 (9): 1383–90. PMID 10224278.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Xia C, Bao Z, Tabassam F, et al. (2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity.". J. Biol. Chem. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
Zhang W, Trible RP, Zhu M, et al. (2000). "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.". J. Biol. Chem. 275 (30): 23355–61. doi:10.1074/jbc.M000404200. PMID 10811803.
Ellis JH, Ashman C, Burden MN, et al. (2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.". J. Immunol. 164 (11): 5805–14. PMID 10820259.
Ma W, Xia C, Ling P, et al. (2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes.". Oncogene 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
Poetsch A, Molday LL, Molday RS (2002). "The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes.". J. Biol. Chem. 276 (51): 48009–16. doi:10.1074/jbc.M108941200. PMID 11641407.
Wenzel J, Sanzenbacher R, Ghadimi M, et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.". FEBS Lett. 509 (2): 255–62. PMID 11741599.
Bourgin C, Bourette RP, Arnaud S, et al. (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.". Mol. Cell. Biol. 22 (11): 3744–56. PMID 11997510.
Guyot B, Arnaud S, Phothirath P, et al. (2002). "Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters.". Gene 290 (1-2): 173–9. PMID 12062812.
Lindholm CK, Henriksson ML, Hallberg B, Welsh M (2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.". Eur. J. Biochem. 269 (13): 3279–88. PMID 12084069.
Zhu M, Janssen E, Leung K, Zhang W (2003). "Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.". J. Biol. Chem. 277 (48): 46151–8. doi:10.1074/jbc.M208946200. PMID 12359715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Guyot B, Arnaud S, Phothirath P, et al. (2003). "Upstream open reading frames regulate translation of Mona/Gads adapter mRNA in the megakaryocytic lineage.". Platelets 13 (8): 459–64. doi:10.1080/0953710021000059431. PMID 12487779.
Yankee TM, Solow SA, Draves KD, Clark EA (2003). "Expression of the Grb2-related protein of the lymphoid system in B cell subsets enhances B cell antigen receptor signaling through mitogen-activated protein kinase pathways.". J. Immunol. 170 (1): 349–55. PMID 12496419.