GPSM2

From Wikipedia, the free encyclopedia

G-protein signalling modulator 2 (AGS3-like, C. elegans)

Identifiers

GPSM2; LGN; Pins

External IDs

OMIM: 609245 MGI: 1923373 HomoloGene: 56584

Gene ontology
Molecular Function:	• GTPase activator activity • binding • identical protein binding
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013296 (mRNA)
NP_037428 (protein)

NM_029522 (mRNA)
NP_083798 (protein)

Location

Chr 1: 109.22 - 109.27 Mb

Chr 3: 108.81 - 108.85 Mb

Pubmed search

[1]

[2]

G-protein signalling modulator 2 (AGS3-like, C. elegans), also known as GPSM2, is a human gene.^[1]

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans).

[edit] Further reading

Mochizuki N, Cho G, Wen B, Insel PA (1997). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2.". Gene 181 (1-2): 39–43. PMID 8973305.
Du Q, Stukenberg PT, Macara IG (2002). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization.". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
Blumer JB, Chandler LJ, Lanier SM (2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis.". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras.". Mol. Cell. Biol. 23 (11): 3847–58. PMID 12748287.
Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression.". Mol. Biol. Cell 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMID 12925752.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.". Cell 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
Yasumi M, Sakisaka T, Hoshino T, et al. (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
Yang J, Kamide K, Kokubo Y, et al. (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population.". J. Hypertens. 23 (8): 1497–505. PMID 16003176.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.