GPS2 (gene)

From Wikipedia, the free encyclopedia

G protein pathway suppressor 2

Identifiers

GPS2; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289

External IDs

OMIM: 601935 MGI: 1891751 HomoloGene: 49599

Gene ontology
Molecular Function:	• GTPase inhibitor activity • protein binding
Biological Process:	• inactivation of MAPK activity • cell cycle • JNK cascade

Orthologs

Human

Mouse

Entrez

2874

56310

Refseq

NM_004489 (mRNA)
NP_004480 (protein)

NM_019726 (mRNA)
NP_062700 (protein)

Pubmed search

[1]

[2]

G protein pathway suppressor 2, also known as GPS2, is a human gene.^[1]

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.^[1]

[edit] References

^ ^a ^b Entrez Gene: GPS2 G protein pathway suppressor 2.

[edit] Further reading

Spain BH, Bowdish KS, Pacal AR, et al. (1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.". Mol. Cell. Biol. 16 (12): 6698–706. PMID 8943324.
Jin DY, Teramoto H, Giam CZ, et al. (1997). "A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.". J. Biol. Chem. 272 (41): 25816–23. PMID 9325311.
Peng YC, Breiding DE, Sverdrup F, et al. (2000). "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins.". J. Virol. 74 (13): 5872–9. PMID 10846067.
Degenhardt YY, Silverstein SJ (2001). "Gps2, a protein partner for human papillomavirus E6 proteins.". J. Virol. 75 (1): 151–60. doi:10.1128/JVI.75.1.151-160.2001. PMID 11119584.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Peng YC, Kuo F, Breiding DE, et al. (2001). "AMF1 (GPS2) modulates p53 transactivation.". Mol. Cell. Biol. 21 (17): 5913–24. PMID 11486030.
Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.". Mol. Cell 9 (3): 611–23. PMID 11931768.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMID 12628926.
Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.". Mol. Cell 12 (3): 723–34. PMID 14527417.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Diederichs S, Bäumer N, Ji P, et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.". J. Biol. Chem. 279 (32): 33727–41. doi:10.1074/jbc.M401708200. PMID 15159402.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lee TH, Yi W, Griswold MD, et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.". DNA Repair (Amst.) 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Sanyal S, Båvner A, Haroniti A, et al. (2007). "Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.". Proc. Natl. Acad. Sci. U.S.A. 104 (40): 15665–70. doi:10.1073/pnas.0706736104. PMID 17895379.