GPR56

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G protein-coupled receptor 56
Identifiers
Symbol(s) GPR56; BFPP; DKFZp781L1398; TM7LN4; TM7XN1
External IDs OMIM: 604110 MGI: 1340051 HomoloGene: 4156
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9289 14766
Ensembl ENSG00000205336 ENSMUSG00000031785
Uniprot Q9Y653 Q8K209
Refseq NM_005682 (mRNA)
NP_005673 (protein)		 NM_018882 (mRNA)
NP_061370 (protein)
Location Chr 16: 56.24 - 56.26 Mb Chr 8: 97.87 - 97.9 Mb
Pubmed search [1] [2]

G protein-coupled receptor 56, also known as GPR56, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: GPR56 G protein-coupled receptor 56.

[edit] Further reading

  • Xu L, Hynes RO (2007). "GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.". Cell Cycle 6 (2): 160–5. PMID 17314516. 
  • Liu M, Parker RM, Darby K, et al. (1999). "GPR56, a novel secretin-like human G-protein-coupled receptor gene.". Genomics 55 (3): 296–305. doi:10.1006/geno.1998.5644. PMID 10049584. 
  • Zendman AJ, Cornelissen IM, Weidle UH, et al. (1999). "TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential.". FEBS Lett. 446 (2-3): 292–8. PMID 10100861. 
  • Piao X, Basel-Vanagaite L, Straussberg R, et al. (2002). "An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.". Am. J. Hum. Genet. 70 (4): 1028–33. PMID 11845408. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Little KD, Hemler ME, Stipp CS (2005). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.". Mol. Biol. Cell 15 (5): 2375–87. doi:10.1091/mbc.E03-12-0886. PMID 15004227. 
  • Piao X, Hill RS, Bodell A, et al. (2004). "G protein-coupled receptor-dependent development of human frontal cortex.". Science 303 (5666): 2033–6. doi:10.1126/science.1092780. PMID 15044805. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shashidhar S, Lorente G, Nagavarapu U, et al. (2005). "GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.". Oncogene 24 (10): 1673–82. doi:10.1038/sj.onc.1208395. PMID 15674329. 
  • Sud N, Sharma R, Ray R, et al. (2006). "Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.". Cancer Lett. 233 (2): 265–70. doi:10.1016/j.canlet.2005.03.018. PMID 15916848. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Xu L, Begum S, Hearn JD, Hynes RO (2006). "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. doi:10.1073/pnas.0602681103. PMID 16757564. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened