GPR15

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G protein-coupled receptor 15
Identifiers
Symbol(s) GPR15; MGC126828; MGC126830
External IDs OMIM: 601166 MGI: 1918473 HomoloGene: 3869
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2838 71223
Ensembl ENSG00000154165 ENSMUSG00000047293
Uniprot P49685 n/a
Refseq NM_005290 (mRNA)
NP_005281 (protein)		 XM_001002039 (mRNA)
XP_001002039 (protein)
Location Chr 3: 99.73 - 99.73 Mb Chr 16: 58.66 - 58.66 Mb
Pubmed search [1] [2]

G protein-coupled receptor 15, also known as GPR15, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: GPR15 G protein-coupled receptor 15.

[edit] Further reading

  • Cunningham AL, Li S, Juarez J, et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245. 
  • Heiber M, Marchese A, Nguyen T, et al. (1997). "A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.". Genomics 32 (3): 462–5. doi:10.1006/geno.1996.0143. PMID 8838812. 
  • Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses.". Nature 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441. 
  • Farzan M, Choe H, Martin K, et al. (1997). "Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.". J. Exp. Med. 186 (3): 405–11. PMID 9236192. 
  • Clayton F, Kotler DP, Kuwada SK, et al. (2001). "Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.". Am. J. Pathol. 159 (5): 1933–9. PMID 11696454. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Croitoru-Lamoury J, Guillemin GJ, Boussin FD, et al. (2003). "Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation.". Glia 41 (4): 354–70. doi:10.1002/glia.10181. PMID 12555203. 
  • Maresca M, Mahfoud R, Garmy N, et al. (2003). "The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line.". J. Biomed. Sci. 10 (1): 156–66. doi:10.1159/000068089. PMID 12566994. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Blaak H, Boers PH, Gruters RA, et al. (2005). "CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.". J. Virol. 79 (3): 1686–700. doi:10.1128/JVI.79.3.1686-1700.2005. PMID 15650194. 
  • Cilliers T, Willey S, Sullivan WM, et al. (2005). "Use of alternate coreceptors on primary cells by two HIV-1 isolates.". Virology 339 (1): 136–44. doi:10.1016/j.virol.2005.05.027. PMID 15992849. 
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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened