GPR132

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G protein-coupled receptor 132
Identifiers
Symbol(s) GPR132; G2A; MGC99642
External IDs OMIM: 606167 MGI: 1890220 HomoloGene: 8350
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29933 56696
Ensembl ENSG00000183484 ENSMUSG00000021298
Uniprot Q9UNW8 Q0VBS4
Refseq NM_013345 (mRNA)
NP_037477 (protein)		 NM_019925 (mRNA)
NP_064309 (protein)
Location Chr 14: 104.59 - 104.6 Mb Chr 12: 113.3 - 113.31 Mb
Pubmed search [1] [2]

G protein-coupled receptor 132, also known as GPR132, is a human gene.[1]

This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.[1]

[edit] References

  1. ^ a b Entrez Gene: GPR132 G protein-coupled receptor 132.

[edit] Further reading

  • Weng Z, Fluckiger AC, Nisitani S, et al. (1998). "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334–9. PMID 9770487. 
  • Kabarowski JH, Zhu K, Le LQ, et al. (2001). "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.". Science 293 (5530): 702–5. doi:10.1126/science.1061781. PMID 11474113. 
  • Le LQ, Kabarowski JH, Wong S, et al. (2002). "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene.". Cancer Cell 1 (4): 381–91. PMID 12086852. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rikitake Y, Hirata K, Yamashita T, et al. (2002). "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049–53. PMID 12482833. 
  • Lin P, Ye RD (2003). "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.". J. Biol. Chem. 278 (16): 14379–86. doi:10.1074/jbc.M209101200. PMID 12586833. 
  • Lum H, Qiao J, Walter RJ, et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023. 
  • Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). "G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.". J. Biol. Chem. 279 (41): 42484–91. doi:10.1074/jbc.M406561200. PMID 15280385. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Witte ON, Kabarowski JH, Xu Y, et al. (2005). "Retraction.". Science 307 (5707): 206. doi:10.1126/science.307.5707.206b. PMID 15653487. 
  • Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMID 15665078. 
  • Obinata H, Hattori T, Nakane S, et al. (2006). "Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.". J. Biol. Chem. 280 (49): 40676–83. doi:10.1074/jbc.M507787200. PMID 16236715. 
  • Frasch SC, Zemski-Berry K, Murphy RC, et al. (2007). "Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.". J. Immunol. 178 (10): 6540–8. PMID 17475884. 

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened