GPLD1

From Wikipedia, the free encyclopedia

Glycosylphosphatidylinositol specific phospholipase D1

Identifiers

GPLD1; GPIPLD; GPIPLDM; MGC22590; PIGPLD; PIGPLD1

External IDs

OMIM: 602515 MGI: 106604 HomoloGene: 1152

Gene ontology
Molecular Function:	• glycosylphosphatidylinositol phospholipase D activity • hydrolase activity
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• GPI anchor release

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001503 (mRNA)
NP_001494 (protein)

NM_008156 (mRNA)
NP_032182 (protein)

Location

Chr 6: 24.54 - 24.6 Mb

Chr 13: 24.95 - 25 Mb

Pubmed search

[1]

[2]

Glycosylphosphatidylinositol specific phospholipase D1, also known as GPLD1, is a human gene.^[1]

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.^[1]

[edit] References

^ ^a ^b Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1.

[edit] Further reading

Hoener MC, Brodbeck U (1992). "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins.". Eur. J. Biochem. 206 (3): 747–57. PMID 1606959.
Scallon BJ, Fung WJ, Tsang TC, et al. (1991). "Primary structure and functional activity of a phosphatidylinositol-glycan-specific phospholipase D.". Science 252 (5004): 446–8. PMID 2017684.
Metz CN, Brunner G, Choi-Muira NH, et al. (1994). "Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D.". EMBO J. 13 (7): 1741–51. PMID 7512501.
Jinnai H, Nakamura S (2000). "Characterization of phospholipase D activation by GM2 activator in a cell-free system.". The Kobe journal of medical sciences 45 (3-4): 181–90. PMID 10752311.
Schofield JN, Rademacher TW (2000). "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.". Biochim. Biophys. Acta 1494 (1-2): 189–94. PMID 11072085.
Deeg MA, Bierman EL, Cheung MC (2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex.". J. Lipid Res. 42 (3): 442–51. PMID 11254757.
Tang J, Li W (2002). "[Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum]". Hunan Yi Ke Da Xue Xue Bao 24 (2): 119–22. PMID 11938765.
Slomiany A, Nishikawa H, Slomiany BL (2002). "Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa.". J. Physiol. Pharmacol. 53 (1): 21–38. PMID 11939716.
Jaworek J, Bonio J, Leja-Szpa A, et al. (2002). "Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin.". J. Physiol. Pharmacol. 53 (1): 51–74. PMID 11939719.
Deeg MA, Bowen RF (2002). "Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D.". Biochem. Cell Biol. 80 (2): 253–60. PMID 11989719.
Xiaotong H, Hannocks MJ, Hampson I, Brunner G (2002). "GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.". Clin. Exp. Metastasis 19 (4): 291–9. PMID 12090469.
Magnusson P, Sharp CA, Farley JR (2003). "Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts.". Clin. Chim. Acta 325 (1-2): 59–70. PMID 12367767.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tang JH, Gu SL, Zhang XJ (2003). "[Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D]". Hunan Yi Ke Da Xue Xue Bao 26 (2): 95–7. PMID 12536633.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Kurtz TA, Fineberg NS, Considine RV, Deeg MA (2004). "Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D.". Metab. Clin. Exp. 53 (2): 138–9. PMID 14767861.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lugli EB, Pouliot M, Portela Mdel P, et al. (2005). "Characterization of primate trypanosome lytic factors.". Mol. Biochem. Parasitol. 138 (1): 9–20. doi:10.1016/j.molbiopara.2004.07.004. PMID 15500911.
Everett PB, Senogles SE (2005). "D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway.". Neurosci. Lett. 371 (1): 34–9. doi:10.1016/j.neulet.2004.08.033. PMID 15500962.
Mead KI, Zheng Y, Manzotti CN, et al. (2005). "Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.". J. Immunol. 174 (8): 4803–11. PMID 15814706.