GPHA2

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Glycoprotein hormone alpha 2
Identifiers
Symbol(s) GPHA2; GPA2; MGC126572; ZSIG51
External IDs OMIM: 609651 MGI: 2156541 HomoloGene: 15605
Orthologs
Human Mouse
Entrez 170589 170458
Ensembl ENSG00000149735 ENSMUSG00000024784
Uniprot Q96T91 Q925Q5
Refseq NM_130769 (mRNA)
NP_570125 (protein)		 NM_130453 (mRNA)
NP_569720 (protein)
Location Chr 11: 64.46 - 64.46 Mb Chr 19: 6.23 - 6.23 Mb
Pubmed search [1] [2]

Glycoprotein hormone alpha 2, also known as GPHA2, is a human gene.[1]

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: GPHA2 glycoprotein hormone alpha 2.

[edit] Further reading

  • Suzuki C, Nagasaki H, Okajima Y, et al. (2007). "The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin.". Regul. Pept. 142 (1-2): 60–7. doi:10.1016/j.regpep.2007.01.009. PMID 17363077. 
  • Breous E, Wenzel A, Loos U (2006). "Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit.". Mol. Cell. Endocrinol. 245 (1-2): 169–80. doi:10.1016/j.mce.2005.11.009. PMID 16376481. 
  • Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.". Endocrinology 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.". Mol. Endocrinol. 16 (7): 1538–51. PMID 12089349. 
  • Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMID 12045258. 
  • Hsu SY, Nakabayashi K, Nishi S, et al. (2002). "Activation of orphan receptors by the hormone relaxin.". Science 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971. 
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