GPC6
From Wikipedia, the free encyclopedia
Glypican 6
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Identifiers | |||||||||||
Symbol(s) | GPC6; MGC126288 | ||||||||||
External IDs | OMIM: 604404 MGI: 1346322 HomoloGene: 55922 | ||||||||||
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RNA expression pattern | |||||||||||
Orthologs | |||||||||||
Human | Mouse | ||||||||||
Entrez | 10082 | 23888 | |||||||||
Ensembl | ENSG00000183098 | ENSMUSG00000058571 | |||||||||
Uniprot | Q9Y625 | Q3TP69 | |||||||||
Refseq | NM_005708 (mRNA) NP_005699 (protein) |
NM_001079844 (mRNA) NP_001073313 (protein) |
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Location | Chr 13: 92.68 - 93.86 Mb | Chr 14: 115.81 - 116.86 Mb | |||||||||
Pubmed search | [1] | [2] |
Glypican 6, also known as GPC6, is a human gene.[1]
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.[1]
[edit] References
[edit] Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi: . PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi: . PMID 15057823.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi: . PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi: . PMID 12477932.
- Veugelers M, De Cat B, Ceulemans H, et al. (1999). "Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans.". J. Biol. Chem. 274 (38): 26968-77. PMID 10480909.
- Paine-Saunders S, Viviano BL, Saunders S (1999). "GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.". Genomics 57 (3): 455-8. doi: . PMID 10329016.
- Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney.". J. Cell Biol. 130 (5): 1207-18. PMID 7657705.