GPC5

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Glypican 5
Identifiers
Symbol(s) GPC5;
External IDs OMIM: 602446 MGI: 1194894 HomoloGene: 3285
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2262 103978
Ensembl ENSG00000179399 ENSMUSG00000022112
Uniprot P78333 O70206
Refseq NM_004466 (mRNA)
NP_004457 (protein)		 NM_175500 (mRNA)
NP_780709 (protein)
Location Chr 13: 90.85 - 92.32 Mb Chr 14: 113.97 - 115.41 Mb
Pubmed search [1] [2]

Glypican 5, also known as GPC5, is a human gene.[1]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[1]

[edit] References

  1. ^ a b Entrez Gene: GPC5 glypican 5.

[edit] Further reading

  • De Cat B, David G (2001). "Developmental roles of the glypicans.". Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377. 
  • Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney.". J. Cell Biol. 130 (5): 1207–18. PMID 7657705. 
  • Veugelers M, Vermeesch J, Reekmans G, et al. (1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.". Genomics 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915. 
  • Saunders S, Paine-Saunders S, Lander AD (1997). "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain.". Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333. 
  • Veugelers M, De Cat B, Delande N, et al. (2002). "A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32.". Matrix Biol. 20 (5-6): 375–85. PMID 11566272. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yu W, Inoue J, Imoto I, et al. (2004). "GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.". J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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