GPC1 (gene)

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Glypican 1
Identifiers
Symbol(s) GPC1; FLJ38078; glypican
External IDs OMIM: 600395 MGI: 1194891 HomoloGene: 20477
Orthologs
Human Mouse
Entrez 2817 14733
Ensembl ENSG00000063660 ENSMUSG00000034220
Uniprot P35052 Q3U379
Refseq NM_002081 (mRNA)
NP_002072 (protein)		 NM_016696 (mRNA)
NP_057905 (protein)
Location Chr 2: 241.02 - 241.06 Mb Chr 1: 94.66 - 94.69 Mb
Pubmed search [1] [2]

Glypican 1, also known as GPC1, is a human gene.[1]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[1]

[edit] References

  1. ^ a b Entrez Gene: GPC1 glypican 1.

[edit] Further reading

  • Karthikeyan L, Maurel P, Rauch U, et al. (1992). "Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican.". Biochem. Biophys. Res. Commun. 188 (1): 395–401. PMID 1417860. 
  • David G, Lories V, Decock B, et al. (1991). "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.". J. Cell Biol. 111 (6 Pt 2): 3165–76. PMID 2148568. 
  • Vermeesch JR, Mertens G, David G, Marynen P (1995). "Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization.". Genomics 25 (1): 327–9. PMID 7774946. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Kleeff J, Ishiwata T, Kumbasar A, et al. (1998). "The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer.". J. Clin. Invest. 102 (9): 1662–73. PMID 9802880. 
  • Gengrinovitch S, Berman B, David G, et al. (1999). "Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165.". J. Biol. Chem. 274 (16): 10816–22. PMID 10196157. 
  • Liang Y, Annan RS, Carr SA, et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain.". J. Biol. Chem. 274 (25): 17885–92. PMID 10364234. 
  • Schofield KP, Gallagher JT, David G (2000). "Expression of proteoglycan core proteins in human bone marrow stroma.". Biochem. J. 343 Pt 3: 663–8. PMID 10527946. 
  • Karumanchi SA, Jha V, Ramchandran R, et al. (2001). "Cell surface glypicans are low-affinity endostatin receptors.". Mol. Cell 7 (4): 811–22. PMID 11336704. 
  • Ronca F, Andersen JS, Paech V, Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1.". J. Biol. Chem. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. PMID 11375980. 
  • Matsuda K, Maruyama H, Guo F, et al. (2001). "Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells.". Cancer Res. 61 (14): 5562–9. PMID 11454708. 
  • Alvarez K, Fadic R, Brandan E (2002). "Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy.". J. Cell. Biochem. 85 (4): 703–13. doi:10.1002/jcb.10184. PMID 11968010. 
  • Ding K, Mani K, Cheng F, et al. (2002). "Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols.". J. Biol. Chem. 277 (36): 33353–60. doi:10.1074/jbc.M203383200. PMID 12084716. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Belting M, Mani K, Jönsson M, et al. (2004). "Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide.". J. Biol. Chem. 278 (47): 47181–9. doi:10.1074/jbc.M308325200. PMID 12972423. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Watanabe N, Araki W, Chui DH, et al. (2004). "Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.". FASEB J. 18 (9): 1013–5. doi:10.1096/fj.03-1040fje. PMID 15084524. 
  • Li J, Kleeff J, Kayed H, et al. (2004). "Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells.". Biochem. Biophys. Res. Commun. 320 (4): 1148–55. doi:10.1016/j.bbrc.2004.06.063. PMID 15249209. 
  • Davies EJ, Blackhall FH, Shanks JH, et al. (2005). "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.". Clin. Cancer Res. 10 (15): 5178–86. doi:10.1158/1078-0432.CCR-03-0103. PMID 15297422. 
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