GPA33

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Glycoprotein A33 (transmembrane)
Identifiers
Symbol(s) GPA33; A33; MGC129986; MGC129987
External IDs OMIM: 602171 MGI: 1891703 HomoloGene: 4245
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10223 59290
Ensembl ENSG00000143167 ENSMUSG00000000544
Uniprot Q99795 Q9JKA5
Refseq NM_005814 (mRNA)
NP_005805 (protein)		 NM_021610 (mRNA)
NP_067623 (protein)
Location Chr 1: 165.29 - 165.33 Mb Chr 1: 167.97 - 168 Mb
Pubmed search [1] [2]

Glycoprotein A33 (transmembrane), also known as GPA33, is a human gene.[1]

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[1]

[edit] References

  1. ^ a b Entrez Gene: GPA33 glycoprotein A33 (transmembrane).

[edit] Further reading

  • Hwang SH, Sohn YH, Oh HB, et al. (2007). "Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans.". Arch. Pathol. Lab. Med. 131 (1): 117–21. PMID 17227111. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mao Z, Song S, Zhu Y, et al. (2003). "Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor.". Oncogene 22 (28): 4434–43. doi:10.1038/sj.onc.1206508. PMID 12853980. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Johnstone CN, White SJ, Tebbutt NC, et al. (2002). "Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.". J. Biol. Chem. 277 (37): 34531–9. doi:10.1074/jbc.M204865200. PMID 12114523. 
  • Moritz RL, Ritter G, Catimel B, et al. (1998). "Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium.". Journal of chromatography. A 798 (1-2): 91–101. PMID 9542130. 
  • Ritter G, Cohen LS, Nice EC, et al. (1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium.". Biochem. Biophys. Res. Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713. 
  • Heath JK, White SJ, Johnstone CN, et al. (1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily.". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 469–74. PMID 9012807. 
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