GOSR2

From Wikipedia, the free encyclopedia

Golgi SNAP receptor complex member 2

Identifiers

GOSR2; Bos1; GS27; MEMBRIN

External IDs

OMIM: 604027 MGI: 1927204 HomoloGene: 37907

Gene ontology
Molecular Function:	• receptor activity • transporter activity • SNAP receptor activity
Cellular Component:	• Golgi membrane • endoplasmic reticulum membrane • membrane • integral to membrane
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • membrane fusion • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012511 (mRNA)
NP_001012529 (protein)

NM_019650 (mRNA)
NP_062624 (protein)

Location

Chr 17: 42.36 - 42.37 Mb

Chr 11: 103.49 - 103.51 Mb

Pubmed search

[1]

[2]

Golgi SNAP receptor complex member 2, also known as GOSR2, is a human gene.^[1]

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: GOSR2 golgi SNAP receptor complex member 2.

[edit] Further reading

Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.". Cell 89 (1): 149–58. PMID 9094723.
Lowe SL, Peter F, Subramaniam VN, et al. (1997). "A SNARE involved in protein transport through the Golgi apparatus.". Nature 389 (6653): 881–4. doi:10.1038/39923. PMID 9349823.
Hay JC, Klumperman J, Oorschot V, et al. (1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs.". J. Cell Biol. 141 (7): 1489–502. PMID 9647643.
Bui TD, Levy ER, Subramaniam VN, et al. (1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17.". Genomics 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID 10198168.
Xu D, Joglekar AP, Williams AL, Hay JC (2001). "Subunit structure of a mammalian ER/Golgi SNARE complex.". J. Biol. Chem. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Honda A, Al-Awar OS, Hay JC, Donaldson JG (2005). "Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE.". J. Cell Biol. 168 (7): 1039–51. doi:10.1083/jcb.200409138. PMID 15781476.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.