Talk:Golgi apparatus

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To-do list for Golgi apparatus:	edit · history · watch · refresh
Needs expansion: Structure (microtubules) Transport mechanisms involving COPII transport vesicles Molecular tagging Diagrams of transport mechanisms Information concerning the above can be found in the online textbook Molecular Biology of the Cell, with a link to the relevant chapter here: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.section.2333

Contents 1 Cis face 2 Pronounciation 3 Survival without Golgi bodies 4 What are the major unknowns left? 5 Cis Face? 6 cis 7 References section looks borked

[edit] Cis face

Shouldn't the cis face outlined in the article be described as that which receives vesicles from the ER? The description actually given appears to be that for the trans face. —Preceding unsigned comment added by 86.143.47.61 (talk) 15:02, 29 December 2007 (UTC)

[edit] Pronounciation

How is Golgi pronounced? Soft or hard 'g's. Does it matter? Jenks 20:55, 1 May 2005 (UTC)

it is pronounced with a hard g.

Goal-guy. This does matter because what if you were in an operating theatre and you said the gauljee body is not functioning? You could be discussing the laws of gravity!The Director 16:36, 23 October 2005 (UTC)

Goal-guy?? only if you're from long island, try Goal-Gee--NY101 16:38, 23 October 2005 (UTC)

What is your source for that pronunciation, because according to http://www.infoplease.com/ce6/people/A0821208.html, the guy's name is pronounced with a soft j, so I'd think the organelle would be pronounced the same way.--CallmeNiel 20:47, 19 January 2006 (UTC)

Actually, the Oxford English Dictionary Online lists the entry with a soft j. It's pronounced, according to the OED as sort of the "gol" (from "golf") + "ge" (from "genie") ---> "goljē" [*Mike Duron]

Slightly off topic, but under what circumstances would an operating theatre need to refer to a subcellular organelle anyway? Unless you're talking about microdissection (which is a lab technique rather than surgery)... I tend to use "gohl-ghee" (hard g), but I'd understand if someone used a soft g. - Confuseddave 143.167.134.103 16:57, 21 February 2006 (UTC)

It is definately pronounced goal-gee —Preceding unsigned comment added by 68.77.132.89 (talk • contribs)

[edit] Survival without Golgi bodies

Would a cell be able to function without the golgi apparatus? —Preceding unsigned comment added by 66.248.96.2 (talk • contribs)

Yes and no to the best of my knowledge. A prokaryotic cell survives without a golgi body, and I'm sure several eukaryotic cells do exist without them (such as red blood cells) however as a general rule it is an integral part of a eukaryotic cell's organelles. -- Serephine ♠ talk - 00:19, 4 December 2006 (UTC)

Prokaryotes do fine without it, but they also have two outter membranes. The inner of the two takes on many of the functions of eukaryotic membrane-bound organelles such as the golgi. Many of the eukaryotic proteins found in the golgi that embed proteins in the membrane are homologous to proteins found in the inner membranes of prokaryotes. So in a sense prokaryotes do have a golgi, or at least something functionaly similar. Erythrocytes, like Seraphine said, have no golgi nor most other organelles for that matter. They are pretty much gutted before being released into the blood. But I think even this is pretty rare for eukaryotes. Most species' red blood cells get to keep their nuclei and various other entrails. (Mommy always said I was special. I guess she was refering to my lack of nuclei) But, for the most part eukaryotes need their golgis. Cells need a steady flow of proteins moving to the membrane, which, for all of us "higher" species, means we need our precious golgis. So I guess Seraphine said it best... "yes and no." --Stable attractor 12:53, 6 January 2007 (UTC)

[edit] What are the major unknowns left?

I just took an undergraduate module on general biology and am extremely fascinated by this Golgi apparatus. But unfortunately very little information is available in the textbook - it seems Wikipedia has more info! However, I think it would be helpful if we knew what exactly are the major areas of the Golgi apparatus that remain unknown: Are the transport systems (to and fro) fully understood? How are the vesicles formed? Are the metabolic processes all described? Is there a list of the proteins which are synthesised/modified at the Golgi?

And btw, what does "a multi joined membrane-bound accumulation" mean? Is that the way biologists describe such structures?

Alveolate 15:24, 30 April 2007 (UTC)

Thanks for the words of praise, this article is somewhat of a pet of mine. That "multi joined membrane-bound accumulation" snuck in one one of my days off by the looks of it, I'm assuming the editor just meant to say, in a round-about way, that the structure of the Golgi is basically just a bunch of joined membranes. I removed that little section as it didn't really contribute anything which wasn't already said.

There are still many unknown when it comes to the Golgi, you've touched on quite a few though. These are all valid questions, and a quick perusal of recent scientific literature confirms that people are indeed asking them. Use your institutional gateway to access journal articles - if you find anything interesting be sure to put it in the article! Cheers, -- Serephine ♠ talk - 08:23, 1 May 2007 (UTC)

"Exocytotic vesicle" should be renamed into "Constitutive vesicle". Secretory proteins that are released through the regulated secretory pathway, such as triggered by Ca²⁺- and cAMP-mediated signaling cascades, are released from the cells through exocytosis of their storage vesicles. Prayingmantis78 23:10, 5 June 2007 (UTC)

Why the hell is this article locked?Realsanpaku 21:14, 12 November 2007 (UTC)

[edit] Cis Face?

When the article talks about Cis face of the Golgi body, near the top, isnt it talking about the Trans-Golgi Network, i.e. the other end? Unless Im mistaken the Cis face is the side where the proteins synthesised by the rough ER enter, and they leave through exocytosis at the TGN end, and not the Cis face? I quote from "Biochemistry" book, by Berg & Stryer (5th Ed), page 309:

"The cis face of the Golgi complex receives vesicles from the ER, and the trans face sends a different set of vesicles to target sites."

[edit] cis

Hello, there is factual errors in the fourth paragraph which states that, "Cis face is the face of Golgi apparatus from which vesicals leave the Golgi apparatus and proceed to further compartments like late endosome (or endosome), cell surface (or plasma membrane), secretory vesicles or vesicular transport goes to this face from late endosomes."

The correction: Cis face should be trans face.

Rowani —Preceding unsigned comment added by Rowani5006 (talk • contribs) 06:00, 25 December 2007 (UTC)

[edit] References section looks borked

The bottom bit looks a bit off, I'm not sure how it's supposed to be changed through editing. :) Hopefully someone else has a clue. 213.161.190.228 (talk) 11:29, 10 January 2008 (UTC)