GOLGB1

From Wikipedia, the free encyclopedia

Golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1

Identifiers

GOLGB1; GCP; GCP372; GIANTIN

External IDs

OMIM: 602500 MGI: 1099447 HomoloGene: 68401

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• Golgi membrane • ER-Golgi intermediate compartment • Golgi apparatus • Golgi stack • membrane • integral to membrane
Biological Process:	• Golgi organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004487 (mRNA)
NP_004478 (protein)

XM_001001861 (mRNA)
XP_001001861 (protein)

Location

Chr 3: 122.87 - 122.95 Mb

Chr 16: 36.79 - 36.85 Mb

Pubmed search

[1]

[2]

Golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1, also known as GOLGB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GOLGB1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1.

[edit] Further reading

Seelig HP, Schranz P, Schröter H, et al. (1994). "Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)". Mol. Cell. Biol. 14 (4): 2564–76. PMID 7511208.
Linstedt AD, Hauri HP (1993). "Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa.". Mol. Biol. Cell 4 (7): 679–93. PMID 7691276.
Sohda M, Misumi Y, Fujiwara T, et al. (1995). "Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex.". Biochem. Biophys. Res. Commun. 205 (2): 1399–408. doi:10.1006/bbrc.1994.2821. PMID 7802676.
Seelig HP, Schranz P, Schröter H, et al. (1994). "Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections.". J. Autoimmun. 7 (1): 67–91. PMID 8198703.
Sönnichsen B, Lowe M, Levine T, et al. (1998). "A role for giantin in docking COPI vesicles to Golgi membranes.". J. Cell Biol. 140 (5): 1013–21. PMID 9490716.
Linstedt AD, Jesch SA, Mehta A, et al. (2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus.". J. Biol. Chem. 275 (14): 10196–201. PMID 10744704.
Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments.". J. Cell Biol. 150 (3): 475–88. PMID 10931861.
Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic.". J. Biol. Chem. 276 (4): 2693–700. doi:10.1074/jbc.M007957200. PMID 11035033.
Sohda M, Misumi Y, Yamamoto A, et al. (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.
Gillingham AK, Pfeifer AC, Munro S (2003). "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.". Mol. Biol. Cell 13 (11): 3761–74. doi:10.1091/mbc.E02-06-0349. PMID 12429822.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Oka T, Ungar D, Hughson FM, Krieger M (2005). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins.". Mol. Biol. Cell 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMID 15004235.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles.". Science 307 (5712): 1095–8. doi:10.1126/science.1108061. PMID 15718469.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rosing M, Ossendorf E, Rak A, Barnekow A (2007). "Giantin interacts with both the small GTPase Rab6 and Rab1.". Exp. Cell Res. 313 (11): 2318–25. doi:10.1016/j.yexcr.2007.03.031. PMID 17475246.