GNPDA1

From Wikipedia, the free encyclopedia

Glucosamine-6-phosphate deaminase 1

PDB rendering based on 1ne7.

Available structures: 1ne7

Identifiers

Symbol(s)

GNPDA1; GPI; GNPI; GNPDA; HLN; KIAA0060

External IDs

OMIM: 601798 MGI: 1347054 HomoloGene: 38054

Gene ontology
Molecular Function:	• glucosamine-6-phosphate deaminase activity • hydrolase activity
Biological Process:	• carbohydrate metabolic process • glucosamine catabolic process • N-acetylglucosamine metabolic process • generation of precursor metabolites and energy • single fertilization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_005471 (mRNA)
NP_005462 (protein)

NM_011937 (mRNA)
NP_036067 (protein)

Location

Chr 5: 141.36 - 141.37 Mb

n/a

Pubmed search

[1]

[2]

Glucosamine-6-phosphate deaminase 1, also known as GNPDA1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1.

[edit] Further reading

Weidanz JA, Campbell P, DeLucas LJ, et al. (1995). "Glucosamine 6-phosphate deaminase in normal human erythrocytes.". Br. J. Haematol. 91 (1): 72–9. PMID 7577655.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044.
Oliva G, Fontes MR, Garratt RC, et al. (1996). "Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution.". Structure 3 (12): 1323–32. PMID 8747459.
Wolosker H, Kline D, Bian Y, et al. (1998). "Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity.". FASEB J. 12 (1): 91–9. PMID 9438414.
Shevchenko V, Hogben M, Ekong R, et al. (1998). "The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization.". Gene 216 (1): 31–8. PMID 9714720.
Nakamura Y, Miura K, Fujino Y, et al. (2001). "Evolution, structure, and expression of GNPI/Oscillin orthologous genes.". Genomics 68 (2): 179–86. doi:10.1006/geno.2000.6287. PMID 10964516.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang J, Zhang W, Zou D, et al. (2003). "Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin.". J. Cell. Biochem. 88 (5): 932–40. doi:10.1002/jcb.10444. PMID 12616532.
Arreola R, Valderrama B, Morante ML, Horjales E (2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study.". FEBS Lett. 551 (1-3): 63–70. PMID 12965206.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.