GNLY

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Granulysin
PDB rendering based on 1l9l.
Available structures: 1l9l
Identifiers
Symbol(s) GNLY; 519; D2S69E; LAG-2; LAG2; NKG5; TLA519
External IDs OMIM: 188855 HomoloGene: 88739
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10578 n/a
Ensembl ENSG00000115523 n/a
Uniprot P22749 n/a
Refseq NM_006433 (mRNA)
NP_006424 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 2: 85.77 - 85.78 Mb n/a
Pubmed search [1] n/a

Granulysin, also known as GNLY, is a human gene.[1]

Granulysin is a protein present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells. Granulysin is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms. Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.[1]

[edit] References

  1. ^ a b Entrez Gene: GNLY granulysin.

[edit] Further reading

  • Peña SV, Krensky AM (1997). "Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity.". Semin. Immunol. 9 (2): 117–25. doi:10.1006/smim.1997.0061. PMID 9194222. 
  • Krensky AM (2000). "Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells.". Biochem. Pharmacol. 59 (4): 317–20. PMID 10644038. 
  • Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11.". Cytogenet. Cell Genet. 53 (4): 230–1. PMID 2209093. 
  • Yabe T, McSherry C, Bach FH, Houchins JP (1990). "A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein.". J. Exp. Med. 172 (4): 1159–63. PMID 2212946. 
  • Jongstra J, Schall TJ, Dyer BJ, et al. (1987). "The isolation and sequence of a novel gene from a human functional T cell line.". J. Exp. Med. 165 (3): 601–14. PMID 2434598. 
  • Houchins JP, Kricek F, Chujor CS, et al. (1993). "Genomic structure of NKG5, a human NK and T cell-specific activation gene.". Immunogenetics 37 (2): 102–7. PMID 8423048. 
  • Peña SV, Hanson DA, Carr BA, et al. (1997). "Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins.". J. Immunol. 158 (6): 2680–8. PMID 9058801. 
  • Stenger S, Hanson DA, Teitelbaum R, et al. (1998). "An antimicrobial activity of cytolytic T cells mediated by granulysin.". Science 282 (5386): 121–5. PMID 9756476. 
  • Hanson DA, Kaspar AA, Poulain FR, Krensky AM (1999). "Biosynthesis of granulysin, a novel cytolytic molecule.". Mol. Immunol. 36 (7): 413–22. PMID 10449094. 
  • Kaspar AA, Okada S, Kumar J, et al. (2001). "A distinct pathway of cell-mediated apoptosis initiated by granulysin.". J. Immunol. 167 (1): 350–6. PMID 11418670. 
  • Kitamura N, Koshiba M, Horie O, Ryo R (2002). "Expression of granulysin mRNA in the human megakaryoblastic leukemia cell line CMK.". Acta Haematol. 108 (1): 13–8. PMID 12145461. 
  • Ma LL, Spurrell JC, Wang JF, et al. (2003). "CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15.". J. Immunol. 169 (10): 5787–95. PMID 12421959. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ericson KG, Fadeel B, Andersson M, et al. (2003). "Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis.". Hum. Genet. 112 (1): 98–9. doi:10.1007/s00439-002-0841-0. PMID 12483306. 
  • Anderson DH, Sawaya MR, Cascio D, et al. (2003). "Granulysin crystal structure and a structure-derived lytic mechanism.". J. Mol. Biol. 325 (2): 355–65. PMID 12488100. 
  • Gansert JL, Kiessler V, Engele M, et al. (2003). "Human NKT cells express granulysin and exhibit antimycobacterial activity.". J. Immunol. 170 (6): 3154–61. PMID 12626573. 
  • Ogawa K, Takamori Y, Suzuki K, et al. (2003). "Granulysin in human serum as a marker of cell-mediated immunity.". Eur. J. Immunol. 33 (7): 1925–33. doi:10.1002/eji.200323977. PMID 12884856. 
  • Kotsch K, Mashreghi MF, Bold G, et al. (2004). "Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection.". Transplantation 77 (12): 1866–75. PMID 15223905. 
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