GNB5

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), beta 5

Identifiers

GNB5; FLJ37457; FLJ43714; GB5

External IDs

OMIM: 604447 MGI: 101848 HomoloGene: 40714

Gene ontology
Molecular Function:	• GTPase activity • signal transducer activity • zinc ion binding
Cellular Component:	• intracellular • heterotrimeric G-protein complex
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006578 (mRNA)
NP_006569 (protein)

NM_010313 (mRNA)
NP_034443 (protein)

Location

Chr 15: 50.2 - 50.27 Mb

Chr 9: 75.1 - 75.13 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), beta 5, also known as GNB5, is a human gene.^[1]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.^[1]

[edit] References

^ ^a ^b Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5.

[edit] Further reading

Downes GB, Gautam N (2000). "The G protein subunit gene families.". Genomics 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.". J. Biol. Chem. 271 (12): 7141–6. PMID 8636150.
Watson AJ, Aragay AM, Slepak VZ, Simon MI (1996). "A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.". J. Biol. Chem. 271 (45): 28154–60. PMID 8910430.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain.". J. Neurosci. 17 (20): 8024–37. PMID 9315921.
Jones PG, Lombardi SJ, Cockett MI (1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA.". Biochim. Biophys. Acta 1402 (3): 288–91. PMID 9606987.
Snow BE, Krumins AM, Brothers GM, et al. (1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307–12. PMID 9789084.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. PMID 10051672.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.". J. Biol. Chem. 274 (43): 31087–93. PMID 10521509.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Blake BL, Wing MR, Zhou JY, et al. (2002). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.
Hu G, Wensel TG (2002). "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9755–60. doi:10.1073/pnas.152094799. PMID 12119397.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ajit SK, Young KH (2004). "Enhancement of pheromone response by RGS9 and Gbeta5 in yeast.". Biochem. Biophys. Res. Commun. 324 (2): 686–91. doi:10.1016/j.bbrc.2004.09.100. PMID 15474482.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.