GNAZ

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), alpha z polypeptide

Identifiers

External IDs

OMIM: 139160 MGI: 95780 HomoloGene: 22574

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • receptor signaling protein activity • GTP binding
Cellular Component:	• nuclear envelope • endoplasmic reticulum • plasma membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002073 (mRNA)
NP_002064 (protein)

NM_010311 (mRNA)
NP_034441 (protein)

Location

Chr 22: 21.74 - 21.8 Mb

Chr 10: 74.41 - 74.46 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), alpha z polypeptide, also known as GNAZ, is a human gene.^[1]

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.^[1]

[edit] References

^ ^a ^b Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide.

[edit] Further reading

Wilkie TM, Gilbert DJ, Olsen AS, et al. (1993). "Evolution of the mammalian G protein alpha subunit multigene family.". Nat. Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014.
Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. PMID 1902575.
Gagnon AW, Manning DR, Catani L, et al. (1991). "Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes.". Blood 78 (5): 1247–53. PMID 1908722.
Matsuoka M, Itoh H, Kaziro Y (1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein.". J. Biol. Chem. 265 (22): 13215–20. PMID 2115889.
Hinton DR, Blanks JC, Fong HK, et al. (1990). "Novel localization of a G protein, Gz-alpha, in neurons of brain and retina.". J. Neurosci. 10 (8): 2763–70. PMID 2117645.
Mumby SM, Heukeroth RO, Gordon JI, Gilman AG (1990). "G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728–32. PMID 2153964.
Matsuoka M, Itoh H, Kozasa T, Kaziro Y (1988). "Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.". Proc. Natl. Acad. Sci. U.S.A. 85 (15): 5384–8. PMID 2456569.
Blatt C, Eversole-Cire P, Cohn VH, et al. (1988). "Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 85 (20): 7642–6. PMID 2902634.
Fong HK, Yoshimoto KK, Eversole-Cire P, Simon MI (1988). "Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.". Proc. Natl. Acad. Sci. U.S.A. 85 (9): 3066–70. PMID 3129724.
Fields TA, Casey PJ (1995). "Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.". J. Biol. Chem. 270 (39): 23119–25. PMID 7559455.
Lounsbury KM, Schlegel B, Poncz M, et al. (1993). "Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.". J. Biol. Chem. 268 (5): 3494–8. PMID 8429024.
Linder ME, Middleton P, Hepler JR, et al. (1993). "Lipid modifications of G proteins: alpha subunits are palmitoylated.". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3675–9. PMID 8475115.
Hunt TW, Fields TA, Casey PJ, Peralta EG (1996). "RGS10 is a selective activator of G alpha i GTPase activity.". Nature 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.
Magovcevic I, Khetarpal U, Bieber FR, Morton CC (1996). "GNAZ in human fetal cochlea: expression, localization, and potential role in inner ear function.". Hear. Res. 90 (1-2): 55–64. PMID 8975005.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. PMID 8986788.
Ho MK, Wong YH (1997). "Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.". J. Neurochem. 68 (6): 2514–22. PMID 9166747.
Sidhu A, Kimura K, Uh M, et al. (1998). "Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.". J. Neurochem. 70 (6): 2459–67. PMID 9603210.
Lin P, Le-Niculescu H, Hofmeister R, et al. (1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein.". J. Cell Biol. 141 (7): 1515–27. PMID 9647645.
Glick JL, Meigs TE, Miron A, Casey PJ (1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha.". J. Biol. Chem. 273 (40): 26008–13. PMID 9748279.